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Updated: May 17, 2026

In Vitro Differentiation of Human CD4+FOXP3+ Induced Regulatory T Cells (iTregs) from Naïve CD4+ T Cells Using a TGF-β-containing Protocol
08:20

In Vitro Differentiation of Human CD4+FOXP3+ Induced Regulatory T Cells (iTregs) from Naïve CD4+ T Cells Using a TGF-β-containing Protocol

Published on: December 30, 2016

新的Foxo1-依赖的转录程序控制T(reg) 细胞功能

Weiming Ouyang1, Will Liao, Chong T Luo

  • 1Immunology Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA.

Nature
|November 9, 2012
PubMed
概括

叉头盒O1 (Foxo1) 对于调节T (Treg) 细胞功能至关重要,维持免疫恒常. 在Treg细胞中删除Foxo1会导致严重的炎症,突出显示了它在Treg细胞最初结合之外的重要作用.

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