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相关概念视频

Anatomy of the Ear01:16

Anatomy of the Ear

Auditory sensation, commonly called hearing, involves the transformation of sonic waves into neural impulses facilitated by the structures of the auditory organ. The prominent, flesh-like structure on the side of the head, called the auricle, directs sound waves towards the auditory canal. The auricle is often mislabeled as the pinna, a term more aligned with mobile structures like a feline's external ear. The auditory canal penetrates the cranium via the external auditory meatus of the...
Equilibrium and Balance01:15

Equilibrium and Balance

The inner ear assumes dual functionalities of auditory perception and equilibrium maintenance. The vestibule is the organ responsible for balance. This organ contains mechanoreceptors, specifically hair cells, endowed with stereocilia, which aid in deciphering information regarding the position and motion of our heads. Two intrinsic components, the utricle and saccule, help perceive head position, while the semicircular canals track head movement. Neurological messages initiated in the...

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相关实验视频

Updated: May 8, 2026

Dissection of Adult Mouse Stria Vascularis for Single-Nucleus Sequencing or Immunostaining
08:51

Dissection of Adult Mouse Stria Vascularis for Single-Nucleus Sequencing or Immunostaining

Published on: April 21, 2023

内耳缺陷和长期条纹性功能障碍之间的因果关系.

Michelle W Antoine1, Christian A Hübner, Joseph C Arezzo

  • 1Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

Science (New York, N.Y.)
|September 7, 2013
PubMed
概括

内耳功能障碍可以通过改变大脑信号通路,导致小鼠过度活跃. 针对这些途径,就像使用PERK抑制剂一样,可以有效地治疗多动性,揭示感官和行为障碍之间的联系.

科学领域:

  • 神经科学是一个神经科学.
  • 感官生物学 感官生物学
  • 行为遗传学 行为遗传学

背景情况:

  • 在内耳功能障碍的个体中,过度活动是常见的.
  • 内耳功能障碍和导致行为障碍的大脑变化之间的联系仍然不清楚.

研究的目的:

  • 调查内耳功能障碍是否可以诱导大脑中的分子变化,导致诸如过度活跃之类的病态行为.
  • 探索特定信号通路在调解内耳功能障碍引起的过活性的作用.

主要方法:

  • 使用Slc12a2突变 (零或组织特异) 的小鼠的分子和行为评估.
  • 在核中测量了化腺3',5'-单反应元素结合蛋白 (pCREB) 和化细胞外信号调节激酶 (pERK) 的水平.
  • 局部服用pERK抑制剂SL327以评估其对多动性的影响.

主要成果:

  • 发现内耳功能障碍会导致小鼠的运动过活.
  • 这种过度活跃与核内核中pCREB和pERK水平的增加有关.
  • 局部使用pERK抑制剂SL327成功地弥补了多动性.

结论:

  • 感觉障碍,如内耳功能障碍,可以诱导特定的分子大脑变化.

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Cryosectioning and Immunostaining Mouse Inner Ear Tissue: From Embryonic to Adult Stages
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Intrathecal Application of a Fluorescent Dye for the Identification of Cerebrospinal Fluid Leaks in Cochlear Malformation
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Last Updated: May 8, 2026

Dissection of Adult Mouse Stria Vascularis for Single-Nucleus Sequencing or Immunostaining
08:51

Dissection of Adult Mouse Stria Vascularis for Single-Nucleus Sequencing or Immunostaining

Published on: April 21, 2023

Cryosectioning and Immunostaining Mouse Inner Ear Tissue: From Embryonic to Adult Stages
09:09

Cryosectioning and Immunostaining Mouse Inner Ear Tissue: From Embryonic to Adult Stages

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Intrathecal Application of a Fluorescent Dye for the Identification of Cerebrospinal Fluid Leaks in Cochlear Malformation
06:59

Intrathecal Application of a Fluorescent Dye for the Identification of Cerebrospinal Fluid Leaks in Cochlear Malformation

Published on: February 29, 2020

  • 这些变化可能导致不适应性行为,如过度活跃,以前认为仅仅是大脑起源.
  • 这些发现突出了感官系统完整性和中枢神经系统行为调节之间的新联系.