Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

DNA Packaging00:58

DNA Packaging

94.7K
Overview
94.7K
DNA Packaging00:58

DNA Packaging

28.9K
28.9K
Genomic DNA in Eukaryotes00:58

Genomic DNA in Eukaryotes

46.0K
Eukaryotes have large genomes compared to prokaryotes. To fit their genomes into a cell, eukaryotic DNA is packaged extraordinarily tightly inside the nucleus. To achieve this, DNA is tightly wound around proteins called histones, which are packaged into nucleosomes that are joined by linker DNA and coil into chromatin fibers. Additional fibrous proteins further compact the chromatin, which is recognizable as chromosomes during certain phases of cell division.
46.0K
Chromatin Packaging01:32

Chromatin Packaging

16.4K
Each human somatic cell contains 6 billion base pairs of DNA. Each base pair is 0.34 nm long, meaning each diploid cell contains a staggering 2 meters of DNA. This long DNA strand is packed inside a nucleus measuring only 10-20 microns in diameter with the help of specialized DNA-binding proteins called histones. Together they form a compact DNA-protein complex called chromatin. The chromatin is further compacted into higher-order structures. The highest level of compaction is achieved during...
16.4K
Chromatin Packaging02:21

Chromatin Packaging

17.0K
Each human somatic cell contains 6 billion base-pairs of DNA. Each base-pair is 0.34 nm long, which means that each diploid cell contains a staggering 2 meters of DNA. How is such a long DNA strand packed inside a nucleus measuring only 10 - 20 microns in diameter? 
The chromatin
In combination with specialized DNA binding protein called Histones, the DNA double helix forms a compact DNA: protein complex called chromatin. The chromatin itself is further compacted into higher-order...
17.0K
The DNA Helix01:16

The DNA Helix

130.1K
Overview
130.1K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Intersegmental transfers drive target search in an RNA-targeting CRISPR system.

bioRxiv : the preprint server for biology·2026
Same author

Multimodal control of Cas13d activity through domain insertion at an allosteric hotspot.

Nature communications·2026
Same author

Towards deployable CRISPR-based nucleic acid detection.

Progress in biomedical engineering (Bristol, England)·2026
Same author

Efficient genome editing with chimeric oligonucleotide-directed editing.

Nature communications·2026
Same author

Highly selective room-temperature ammonia gas sensor based on a sheet-like Ni<sub><i>x</i></sub>C/ZnO heterojunction.

Nanoscale·2026
Same author

Geometrically Well-Controlled Wireframe RNA Nanostructures With Bundled-Helix Edges.

Small (Weinheim an der Bergstrasse, Germany)·2026
Same journal

Linker Engineering toward NIR-II Metal-Organic Framework with Maximal Emission beyond 1000 nm for Inflammatory Bowel Disease Imaging.

Journal of the American Chemical Society·2026
Same journal

Observing Kinetic Selectivity in Anthracene Photodimerization through Selective Quenching by Excited States of Proximate Rare Earth Cations.

Journal of the American Chemical Society·2026
Same journal

Sequence-Dependent Folding of Recognition-Encoded Melamine Oligomers.

Journal of the American Chemical Society·2026
Same journal

Large Thermo- and Mechanosalient Actuation via Cooperative Twist Elasticity-Induced Packing Motif Conversion.

Journal of the American Chemical Society·2026
Same journal

Discovery and Biosynthesis of Lanthipeptides Featuring an Azepinoindole Scaffold by Radical <i>S</i>-Adenosylmethionine Enzyme-Catalyzed C-C Bond Formation.

Journal of the American Chemical Society·2026
Same journal

Enantiopurity-Controlled Magnetism in a Two-Dimensional Organic-Inorganic Material.

Journal of the American Chemical Society·2026
查看所有相关文章

相关实验视频

Updated: May 5, 2026

Design and Synthesis of a Reconfigurable DNA Accordion Rack
07:44

Design and Synthesis of a Reconfigurable DNA Accordion Rack

Published on: August 15, 2018

6.7K

为复杂的DNA结构设计空间.

Bryan Wei1, Mingjie Dai, Cameron Myhrvold

  • 1Wyss Institute for Biologically Inspired Engineering, Harvard Medical School , Boston, Massachusetts 02115, United States.

Journal of the American Chemical Society
|November 22, 2013
PubMed
概括
此摘要是机器生成的。

研究人员利用30多种不同的图案探索了复杂的DNA纳米结构的设计空间. 这项研究揭示了具有多样化的几何性质的广泛结构,扩大了纳米应用的可能性.

更多相关视频

Analyzing and Building Nucleic Acid Structures with 3DNA
16:24

Analyzing and Building Nucleic Acid Structures with 3DNA

Published on: April 26, 2013

20.3K
Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles
10:23

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles

Published on: May 8, 2015

10.9K

相关实验视频

Last Updated: May 5, 2026

Design and Synthesis of a Reconfigurable DNA Accordion Rack
07:44

Design and Synthesis of a Reconfigurable DNA Accordion Rack

Published on: August 15, 2018

6.7K
Analyzing and Building Nucleic Acid Structures with 3DNA
16:24

Analyzing and Building Nucleic Acid Structures with 3DNA

Published on: April 26, 2013

20.3K
Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles
10:23

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles

Published on: May 8, 2015

10.9K

科学领域:

  • 纳米技术 纳米技术
  • 生物材料科学 生物材料科学
  • 结构生物学 结构生物学

背景情况:

  • 核酸,特别是DNA,是自组装纳米结构的多功能构建块.
  • 目前的DNA纳米结构设计受限于对少数常见结构动机的依赖.
  • 需要更广泛的设计空间来优化纳米结构的特定功能应用.

研究的目的:

  • 为了全面研究复杂的DNA纳米结构的设计空间.
  • 探索使用30多种独特的单链DNA图案的多样化.
  • 了解这些图案如何影响结构多样性和几何性质.

主要方法:

  • 用了30多种不同的单链DNA图案进行自我组装实验.
  • 系统地研究和控制组装的DNA纳米结构的曲率.
  • 描述了由此产生的结构,专注于丝织图案和几何特征.

主要成果:

  • 证明了复杂的DNA结构的自我组装,利用各种各样的图案.
  • 实现了多样化的丝织图案和可调的几何性质,如曲率和扭曲.
  • 成功构建了一个平面DNA纳米结构,其特点是波纹链纹.

结论:

  • 这项研究显著扩大了复杂DNA纳米结构的已知设计空间.
  • 这些发现突出了创建具有定制几何性质的新型纳米架构的潜力.
  • 这种扩大的设计空间为开发功能性核酸基纳米材料提供了新的途径.