Search research articles

关于 JoVE

概览领导团队博客 JoVE 帮助中心

作者

出版流程编辑委员会范围与政策同行评审常见问题投稿

图书馆员

用户评价订阅访问资源图书馆顾问委员会常见问题

研究

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments 存档

教育

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual 教师资源中心教师网站

使用条款与条件

相关概念视频

Brain Imaging

Brain Imaging

Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序

Same author

Gold decorated bismuth sulfide nanorods for enhanced computed tomography imaging with in vitro and in vivo validation.

Discover nano·2026

Same author

Fluorescent Sensor for the Visualization of Amino Acid Neurotransmitters in Neurons Based on an S<sub>N</sub>Ar Reaction.

ACS chemical neuroscience·2025

Same author

Imaging Neurotransmitters with Small-Molecule Fluorescent Probes.

Angewandte Chemie (International ed. in English)·2024

Same author

Editorial: Translational advances in Alzheimer's, Parkinson's, and other dementia: molecular mechanisms, biomarkers, diagnosis, and therapies, volume III.

Frontiers in aging neuroscience·2024

Same author

Synthesis of a Near-Infrared Fluorescent Probe for Imaging Catecholamines via a Tandem Nucleophilic Aromatic Substitution.

Organic letters·2023

Same author

Delivery of gene editing therapeutics.

Nanomedicine : nanotechnology, biology, and medicine·2023

Search research articles

相关实验视频

Updated: May 2, 2026

Wide-field Single-photon Optical Recording in Brain Slices Using Voltage-sensitive Dye

Wide-field Single-photon Optical Recording in Brain Slices Using Voltage-sensitive Dye

Published on: June 20, 2019

三个输入逻辑门,对神经元成像有潜在的应用.

Kenneth S Hettie¹, Jessica L Klockow, Timothy E Glass

¹Department of Chemistry, University of Missouri 601 South College Avenue, Columbia, Missouri 65211, United States.

Journal of the American Chemical Society

|March 12, 2014

概括

研究人员开发了新的光分子逻辑门,用于可视化神经递质在外细胞形成过程中释放的神经递质. 这些传感器为研究神经退行性疾病提供了一个新的工具,通过直接对谷氨酸和合释酶进行成像.

科学领域:

神经科学是一个神经科学.
化学生物学化学生物学
分子成像学分子成像学

背景情况:

对神经递质贩运的直接可视化对于理解神经退行性疾病至关重要.
目前的方法缺乏实时监测外细胞发生事件的特异性和便利性.

研究的目的:

开发可调节的光分子逻辑门,用于直接成像神经递质释放.
创建能够检测出酸和在外细胞形成过程中的合释酶的传感器.

主要方法:

基于库马林-3-化物支架的三输入和分子逻辑门的设计和合成.
用光谱学研究来评估在模拟的细胞外条件下的光反应.
基架的甲基化以优化光谱特性和结合研究以阐明传感器-分析物相互作用.

主要成果:

实现了11倍的光增强,模仿了外细胞形成的条件.
通过甲基化为所需的激发波长优化传感器光谱配置.
证明了在外细胞形成过程中释放的神经递质的直接成像的概念验证.

结论:

光分子逻辑门为神经元成像提供了一个新的平台.

更多相关视频

Targeted Labeling of Neurons in a Specific Functional Micro-domain of the Neocortex by Combining Intrinsic Signal and Two-photon Imaging

Targeted Labeling of Neurons in a Specific Functional Micro-domain of the Neocortex by Combining Intrinsic Signal and Two-photon Imaging

Published on: December 12, 2012

Multi-Fiber Photometry to Record Neural Activity in Freely-Moving Animals

Multi-Fiber Photometry to Record Neural Activity in Freely-Moving Animals

Published on: October 20, 2019

相关实验视频

Last Updated: May 2, 2026

Wide-field Single-photon Optical Recording in Brain Slices Using Voltage-sensitive Dye

Wide-field Single-photon Optical Recording in Brain Slices Using Voltage-sensitive Dye

Published on: June 20, 2019

Targeted Labeling of Neurons in a Specific Functional Micro-domain of the Neocortex by Combining Intrinsic Signal and Two-photon Imaging

Targeted Labeling of Neurons in a Specific Functional Micro-domain of the Neocortex by Combining Intrinsic Signal and Two-photon Imaging

Published on: December 12, 2012

Multi-Fiber Photometry to Record Neural Activity in Freely-Moving Animals

Multi-Fiber Photometry to Record Neural Activity in Freely-Moving Animals

Published on: October 20, 2019

这些传感器能够直接可视化神经递质合释酶,有助于神经退行性疾病研究.

开发的传感器代表了神经科学分子工具的重大进步.