简单的,化学选择性的,催化性烯酸异构化.
Steven W M Crossley1, Francis Barabé, Ryan A Shenvi
1Department of Chemistry, The Scripps Research Institute , La Jolla, California 92037, United States.
Journal of the American Chemical Society
|November 15, 2014
概括
催化剂异构终端和循环二烯. 这些催化剂还可以打开紧张的环,耐受各种功能组,如氨基和环氧化物.
科学领域:
- 有机金属化学 有机金属化学
- 催化剂是一种催化剂.
- 有机合成 有机合成
背景情况:
- 烯异构化是有机化学中的一个基本的转化.
- 开发高效和有选择性的催化剂,用于基异构化和相关反应至关重要.
- 了解不同功能组的催化剂行为是实际应用的关键.
研究的目的:
- 为了研究Co(Sal(tBu,tBu))Cl与有机酸盐的催化活性,用于基异构化.
- 探索这些催化剂在二烯的循环异构和应变环的逆循环异构中的作用范围.
- 评估催化系统对各种功能组的耐受性.
主要方法:
- 使用复合物,特别是Co ((Sal ((tBu,tBu)) Cl,作为催化剂.
- 使用有机素作为辅助催化剂或激活剂.
- 研究包括终端烯异构化,二烯循环异构化和张力环开放的反应.
主要成果:
- 催化量Co ((Sal ((tBu,tBu))Cl和有机 irreversibly isomerize终端基的一个位置.
- 催化系统成功地影响了二烯的循环异构化.
- 使用相同的催化剂,也实现了张力环的逆循环异体化.
- 催化剂对强的易斯基 (胺基,伊米达) 和不稳定的功能性 (环氧化物) 具有耐受性.
结论:
- Co(Sal(tBu,tBu))Cl与有机基素一起,为基异构化提供了一个有效的催化系统.
- 催化剂系统表现出多功能性,使烯循环异构化和紧张环开放成为可能.
- 观察到的功能组容忍度扩大了这种催化方法的合成效用.
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