酸盐作为心血管风险因素:对血管和内皮功能的影响
Kathryn K Stevens1, Rajan K Patel1, Patrick B Mark1
1Renal Unit, Western Infirmary, University of Glasgow, Glasgow, UK.
Lancet (London, England)
|August 28, 2015
概括
高酸盐水平直接损害血管功能,导致慢性病患者心血管疾病的风险. 这项研究表明酸盐
科学领域:
- 血管生物学
- 肝脏病学
- 心血管疾病
背景情况:
- 过血是慢性病中心血管疾病的已知危险因素.
- 酸盐与心血管并发症的确切机制尚不清楚,可能包括直接影响,化或FGF23介导.
- 这项研究旨在阐明酸盐对内皮功能的直接影响.
研究的目的:
- 在体外和体内模型中研究酸盐对内皮功能的直接影响.
- 评估酸盐负载是否影响健康志愿者的内皮功能.
- 探索酸盐诱导的内皮功能障碍的潜在机制.
主要方法:
- 用肌图来评估在暴露在正常或高酸盐条件下的隔离大鼠介质血管和人体血管的血管收缩和放松反应.
- 在老鼠血管中的实验包括使用固酶5型抑制剂的评估.
- 在酸盐补充剂或结合剂后,在健康志愿者中进行了一项交叉研究,通过流媒体扩张 (FMD) 测量了内皮功能.
主要成果:
- 在大鼠和人类中,高酸盐显著损害了内皮依赖的血管扩张.
- 在体内,酸盐负载在健康志愿者中减少了口病,这种效应独立于血清酸盐水平,但与尿酸和FGF23有关.
- 用5型化酶抑制剂对大鼠血管的作用是可逆的,这表明NO通路的参与.
结论:
- 长时间的酸盐暴露直接导致内皮功能障碍,可能导致慢性病的心血管风险.
- 在高酸盐条件下,体外和体内的发现都表明血管功能障碍.
- 氧化 (NO) 途径的破坏可能会调解这些酸盐诱导的血管效应.
相关概念视频
Roles of Electrolytes: Calcium and Phosphate
3.6K
Calcium and phosphate are essential electrolytes in the human body, with calcium being the most abundant mineral. Around 99% of the body's calcium is stored in the skeleton and teeth, forming a crystal lattice of mineral salts in combination with phosphates. Calcium plays crucial roles in various bodily functions such as blood clotting, neurotransmitter release, muscle tone maintenance, and nervous and muscle tissue excitability.
The calcium concentration in blood plasma is primarily...
The calcium concentration in blood plasma is primarily...
3.6K
Cardiovascular Drugs: Classification based on Therapeutic Indications
4.6K
Cardiovascular diseases, encompassing a range of conditions, can significantly affect the heart's operations and the overall circulatory system. These conditions impair the heart's ability to pump blood, leading to a deficit in oxygen supply to crucial organs. Anomalies in the heart's electrical system, known as arrhythmias, can cause heartbeats to accelerate or slow down. Usually, heart rates increase during physical activity and decrease while resting or sleeping. However,...
4.6K
Introduction to Electrolytes
18.1K
In humans, electrolytes play a vital role in various physiological processes. Balancing electrolyte levels is essential for normal body functions; their imbalance can be life-threatening. The major electrolytes include sodium, potassium, chloride, calcium, phosphate, and bicarbonate. They are primarily involved in physiological processes, such as nerve signal transmission, membrane trafficking, muscle contraction, buffering body fluids, and balancing water levels in the body.
Role of Sodium
One...
Role of Sodium
One...
18.1K
Blood Studies for Cardiovascular System III: Serum Lipid Profile
849
Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
849
Pathophysiology of Cardiac Performance
2.0K
Typical heart performance is influenced by heart rate, rhythm, myocardial contraction, and metabolism or blood flow. The cardiac muscle exhibits distinct electrophysiological features, including pacemaker activity and calcium channel control, which play a vital role in the heart's response to various drugs. The autonomic nervous system, comprising the sympathetic and parasympathetic branches, regulates heart rate. Sympathetic activation increases heart rate, while parasympathetic activation...
2.0K
Transducer Mechanism: Enzyme-Linked Receptors
4.9K
Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. Drugs can bind to the extracellular ligand-binding domain or directly affect their enzymatic domain and alter their activity.
Major types that are helpful drug targets include:
Major types that are helpful drug targets include:
4.9K


