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Updated: Mar 3, 2026

Synthesis, Functionalization, and Characterization of Fusogenic Porous Silicon Nanoparticles for Oligonucleotide Delivery
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基于半孔纳米颗粒的病原体特定货物交付平台

Bastian Ruehle1, Daniel L Clemens1, Bai-Yu Lee1

  • 1Department of Chemistry and Biochemistry, ‡California NanoSystems Institute, and §Division of Infectious Diseases, Department of Medicine, University of California , Los Angeles, California 90095, United States.

Journal of the American Chemical Society
|April 25, 2017
PubMed
概括

我们开发了一种新的纳米系统, 这种平台可确保特定病原体的药物输送,尽量减少对健康组织的伤害.

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Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
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