相关概念视频
01:43Incomplete Dominance
30.5K
Gregor Mendel's work (1822 - 1884) was primarily focused on pea plants. Through his initial experiments, he determined that every gene in a diploid cell has two variants called alleles inherited from each parent. He suggested that amongst these two alleles, one allele is dominant in character and the other recessive. The combination of alleles determines the phenotype of a gene in an organism.
30.5K
01:09Epistasis Analysis
6.0K
Although Mendel chose seven unrelated traits in peas to study gene segregation, most traits involve multiple gene interactions that create a spectrum of phenotypes. When the interaction of various genes or alleles at different locations influences a phenotype, this is called epistasis. Epistasis often involves one gene masking or interfering with the expression of another (antagonistic epistasis). Epistasis often occurs when different genes are part of the same biochemical pathway. The...
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02:27Background and Environment Affect Phenotype
7.8K
Although the genetic makeup of an organism plays a major role in determining the phenotype, there are also several environmental factors, such as temperature, oxygen availability, presence of mutagens, that can alter an organism’s phenotype.
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...
7.8K
01:49Law of Segregation
78.5K
When crossing pea plants, Mendel noticed that one of the parental traits would sometimes disappear in the first generation of offspring, called the F1 generation, and could reappear in the next generation (F2). He concluded that one of the traits must be dominant over the other, thereby causing masking of one trait in the F1 generation. When he crossed the F1 plants, he found that 75% of the offspring in the F2 generation had the dominant phenotype, while 25% had the recessive phenotype.
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01:49Multiple Allele Traits
38.3K
The Concept of Multiple Allelism
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01:39Epistasis
50.5K
In addition to multiple alleles at the same locus influencing traits, numerous genes or alleles at different locations may interact and influence phenotypes in a phenomenon called epistasis. For example, rabbit fur can be black or brown depending on whether the animal is homozygous dominant or heterozygous at a TYRP1 locus. However, if the rabbit is also homozygous recessive at a locus on the tyrosinase gene (TYR), it will have an unshaded coat that appears white, regardless of its TYRP1...
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相关实验视频
Updated: Feb 21, 2026
08:41
Quantifying Abdominal Pigmentation in Drosophila melanogaster
Published on: June 1, 2017
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编辑表型:定量遗传学的革命
1Division of Biological Sciences, University of Missouri, Columbia, MO 65211, USA.
Cell
|October 7, 2017
概括
研究人员开发了一种促进器编辑方法来研究微妙的遗传变异. 这种方法有助于分析定量特征基因及其复杂的相互作用,进步遗传研究.
科学领域:
- 遗传学
- 分子生物学
背景情况:
- 由于自然遗传变异的微妙影响,分析定量性特征基因具有挑战性.
- 了解这些变异的功能影响对于遗传学研究至关重要.
研究的目的:
- 开发一种用于分析定量特征基因的新型促销器编辑方法.
- 为详细的遗传研究生成有效的等位基因谱.
主要方法:
- 使用促销者编辑策略创建多样化的等位基因.
- 应用生成的等位基因来研究基因功能和相互作用.
主要成果:
- 通过促销器编辑成功生成了一系列有效的等位基因.
- 证明了这种方法在研究微妙的遗传变异方面的实用性.
结论:
- 促销者编辑方法为研究定量特征基因提供了强大的新途径.
- 这种方法有助于研究具有微妙影响的基因之间的复杂相互作用.
