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相关概念视频

RNA Structure01:23

RNA Structure

78.6K
Overview
The basic structure of RNA consists of a five-carbon sugar and one of four nitrogenous bases. Although most RNA is single-stranded, it can form complex secondary and tertiary structures. Such structures play essential roles in the regulation of transcription and translation.
Different Types of RNA Have the Same Basic Structure
There are three main types of ribonucleic acid (RNA): messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). All three RNA types consist of a...
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RNA Structure01:19

RNA Structure

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The basic structure of RNA consists of a string of ribonucleotides attached by phosphodiester bonds. Although most RNA is single-stranded, it can form complex secondary and tertiary structures. Such structures play essential roles in the regulation of transcription and translation.
Different Types of RNA Have the Same Basic Structure
There are three main types of ribonucleic acid (RNA) involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). All three...
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Nucleic Acid Structure01:25

Nucleic Acid Structure

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The pentose sugar in DNA is deoxyribose, while in RNA the pentose sugar is ribose. The difference between the sugars is the presence of the hydroxyl group on the ribose's second carbon and a hydrogen on the deoxyribose's second carbon. The phosphate residue attaches to the hydroxyl group of the 5′ carbon of one sugar and the hydroxyl group of the 3′ carbon of the sugar of the next nucleotide, which forms  a 5′ to 3′ phosphodiester linkage.
DNA Structure
DNA...
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RNA-seq03:21

RNA-seq

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RNA sequencing, or RNA-Seq, is a high-throughput sequencing technology used to study the transcriptome of a cell. Transcriptomics helps to interpret the functional elements of a genome and identify the molecular constituents of an organism. Additionally, it also helps in understanding the development of an organism and the occurrence of diseases. 
Before the discovery of RNA-seq, microarray-based methods and Sanger sequencing were used for transcriptome analysis. However, while...
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RNA Secondary Structure Prediction Using High-throughput SHAPE
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RNA Secondary Structure Prediction Using High-throughput SHAPE

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视觉化无序单链RNA:连接序列,结构和静电学

Alex Plumridge1, Kurt Andresen2, Lois Pollack1

  • 1School of Applied and Engineering Physics , Cornell University , Ithaca , New York 14853 , United States.

Journal of the American Chemical Society
|December 6, 2019
PubMed
概括
此摘要是机器生成的。

单链RNA同聚合物如U和A段具有不同的结构和离子大气层. 这些依赖序列的特性影响RNA折叠和蛋白质相互作用.

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科学领域:

  • 生物化学
  • 分子生物学
  • 生物物理

背景情况:

  • 在功能单链RNA (ssRNA) 中,同聚合物区域 (例如U或A段) 对于分子结构和伴侣识别至关重要.
  • 这些ssRNA基因的精确构造性和生物物理性质尚不完全理解.

研究的目的:

  • 研究生物学意义上的ssRNA同聚合物的构造和离子大气层.
  • 提供ssRNA中U和A段的生物物理特征的定量测量.

主要方法:

  • 应用多种实验技术来探测ssRNA结构.
  • 围绕ssRNA同聚物的离子大气的定量测量.

主要成果:

  • ssRNA结构依赖于序列,吸引独特的离子大气层.
  • 聚U (rU) 链通常是无结构的,而聚A (rA) 链则通过堆叠或聚类来排序,受溶液条件的影响.
  • 观察到的结构差异与离子组成和大气的测量差异相关.

结论:

  • 在RNA基,离子和ssRNA序列之间存在复杂的相互作用.
  • ssRNA同聚物的独特结构和离子特征解释了它们在RNA折叠和蛋白质识别中的作用.