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相关概念视频

Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Histone Modification02:32

Histone Modification

The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone deacetylase,...
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
Histone Modification02:32

Histone Modification

The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone deacetylase,...

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Gene repression paradigms in animal cells.

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相关实验视频

Updated: Jul 1, 2026

Correlating Gene-specific DNA Methylation Changes with Expression and Transcriptional Activity of Astrocytic KCNJ10 (Kir4.1)
11:19

Correlating Gene-specific DNA Methylation Changes with Expression and Transcriptional Activity of Astrocytic KCNJ10 (Kir4.1)

Published on: September 26, 2015

基因甲基化和基因活动

H Cedar1

  • 1Department of Cellular Biochemistry, Hebrew University, Jerusalem, Israel.

Cell
|April 8, 1988
PubMed
概括

通过改变染色质结构,DNA甲基化抑制组织特异性基因,使它们无法访问. 基因激活涉及去甲基化,允许构成性表达.

科学领域:

  • 分子生物学分子生物学
  • 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
  • 基因规则 基因规则

背景情况:

  • 基因甲基化是一种关键的表观遗传机制.
  • 组织特异性基因表达对于细胞分化至关重要.
  • 了解基因抑制机制对于发育生物学至关重要.

研究的目的:

  • 阐明DNA甲基化在调节组织特异性基因表达中的作用 in vivo.
  • 提出一种模型,说明DNA甲基化如何对转录抑制产生影响.
  • 为了解释涉及DNA脱甲基化的基因激活过程.

主要方法:

  • 该研究基于实验发现 (摘要中没有提供细节).
  • 该模型整合了染色质结构和基因可访问性的概念.
  • 涉及组织特异性和家政基因的比较分析.

主要成果:

  • 大多数组织特异性基因被甲基化,导致转录不活.
  • 甲基化会产生一种染色质状态,阻止基因访问.
  • 家政基因通常不会受到这种甲基化诱导的抑制的影响.
  • 基因激活始于对甲基化基因的识别,其次是去甲基化.

更多相关视频

Immunostaining for DNA Modifications: Computational Analysis of Confocal Images
09:42

Immunostaining for DNA Modifications: Computational Analysis of Confocal Images

Published on: September 7, 2017

Continuous Fluorescence-Based Endonuclease-Coupled DNA Methylation Assay to Screen for DNA Methyltransferase Inhibitors
06:07

Continuous Fluorescence-Based Endonuclease-Coupled DNA Methylation Assay to Screen for DNA Methyltransferase Inhibitors

Published on: August 5, 2022

相关实验视频

Last Updated: Jul 1, 2026

Correlating Gene-specific DNA Methylation Changes with Expression and Transcriptional Activity of Astrocytic KCNJ10 (Kir4.1)
11:19

Correlating Gene-specific DNA Methylation Changes with Expression and Transcriptional Activity of Astrocytic KCNJ10 (Kir4.1)

Published on: September 26, 2015

Immunostaining for DNA Modifications: Computational Analysis of Confocal Images
09:42

Immunostaining for DNA Modifications: Computational Analysis of Confocal Images

Published on: September 7, 2017

Continuous Fluorescence-Based Endonuclease-Coupled DNA Methylation Assay to Screen for DNA Methyltransferase Inhibitors
06:07

Continuous Fluorescence-Based Endonuclease-Coupled DNA Methylation Assay to Screen for DNA Methyltransferase Inhibitors

Published on: August 5, 2022

  • 脱甲基基因采用稳定,活跃的染色质结构.

    • 结论:

    • 基因甲基化提供了一个转录抑制的一般机制,独立于调节因素.
    • 这种机制允许差异性基因表达,使细胞类型的特异性.
    • 脱甲基化对于组织特异性基因的稳定激活和维持至关重要.