在整个SARS-CoV-2感染过程中估计感染性
Terry C Jones1,2,3, Guido Biele4,5, Barbara Mühlemann1,2
1Institute of Virology, Charité--Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 10117 Berlin, Germany.
概括
在超过25,000例SARS-CoV-2感染中分析了病毒载量和复制概率. 与其他菌株相比,B.1.1.7变种的病毒载量和复制潜力显著增加.
科学领域:
- 病毒学
- 传染性疾病
- 公共卫生
背景情况:
- 量化病毒感染和泄漏对于了解疾病传播至关重要.
- 病毒载量和复制能力是评估感染性的关键参数.
研究的目的:
- 在大量 SARS-CoV-2 感染者中分析病毒载荷和细胞培养复制概率.
- 将这些参数与不同患者组 (PAMS,住院患者) 和B.1.1.7变种进行比较.
主要方法:
- 德国25381例SARS-CoV-2病例的分析.
- 病毒载荷的量化 (每个样本的RNA拷贝) 和细胞培养分离的概率.
- 基于年龄,症状状况和病毒系的参数比较 (B.1.1.7).
主要成果:
- 年轻人病毒载量和复制概率较低,可能不具有临床意义.
- 8%的受试者病毒载量> 10^9副本/抽样,其中三分之一是PAMS.
- 与非B.1.1.7感染者相比,B.1.1.7感染者平均病毒载量高1.05倍,复制概率高2.6倍.
- 流血开始后大约4. 3天,病毒载量和隔离概率达到峰值.
结论:
- B.1.1.7 变种显示病毒载量增加和复制效率提高.
- 了解病毒分泌动态和变种特征对于感染控制至关重要.
- 病毒载量和复制概率是评估SARS-CoV-2传染性的重要指标.
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