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诺斯提克酸是一种选择性体转录调节剂

Julie M Garlick1,2, Steven M Sturlis1,2, Paul A Bruno1,2

  • 1Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, United States.

Journal of the American Chemical Society
|June 17, 2021
PubMed
概括

通过针对动态循环,诺斯酸阻断了Med25介导的转录,从而提供了新的治疗策略. 这一发现为抑制癌症,特别是三阴性乳腺癌的蛋白蛋白相互作用 (PPI) 开辟了道路.

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Gene transcription is regulated by the synergistic action of several proteins that form a complex at a gene regulatory site. This is observed in eukaryotes, where the regulation of gene expression is a complex process. Regulatory proteins in eukaryotes can broadly be classified into two types – regulators that bind directly to specific DNA sequences and co-regulators that associate with regulatory proteins but cannot directly bind to the DNA. These co-regulators are further divided into...
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