Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Adherens Junctions01:24

Adherens Junctions

5.0K
Strong contact points between adjacent cells anchor them to each other, forming tissues. Such anchoring junctions are of two types –  adherens junctions and desmosomes. Adherens junctions are abundant in tissues such as  epithelium and endothelium, forming a continuous zone of adhesion called the adhesion belt. In other tissues, such as  heart muscle, they appear as clusters, linking the cells to produce coordinated heart muscle contraction.
Adherens Junctions are Dynamic
5.0K
Tension Response at Adherens Junctions01:26

Tension Response at Adherens Junctions

2.8K
The adherens junctions that anchor cells together are multi-protein complexes that dynamically adapt to mechanical stimuli such as tensile forces and shear stress. Mechanosensory proteins in these junctions can sense such mechanical stimuli and undergo a shift in their conformation, resulting in an altered function — a process called mechanotransduction.
α-Catenin as a Mechanosensory Protein
The α-catenin of adherens junctions is an allosteric protein with three VH (vinculin...
2.8K
Adhesion01:14

Adhesion

40.7K
Adhesion occurs when one type of molecule is attracted to a different molecule. Water exhibits adhesive properties in the presence of polar surfaces, such as glass or cellulose in plants. For instance, when water is poured into a glass, the positively charged hydrogen molecules of water are more attracted to the negatively charged oxygen molecules in the silica than to the oxygen in neighboring water molecules.
Capillary action is a result of water’s adhesive tendencies. When a narrow...
40.7K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Enhancing safety in freeway on-ramp merging: Takeover warning through dynamic trust and risk perception modelling considering driving style.

Accident; analysis and prevention·2026
Same author

Long-lived pauses reveal tunable kinetic barriers during Holliday junction migration.

Nucleic acids research·2026
Same author

Rational design of rigid mRNA folding architecture to enhance intracellular processing and protein production.

Nature nanotechnology·2026
Same author

Single-molecule magnetic tweezers reveal distinct dynamics and enhanced mechanical stability of ssDNA 31 and 52 knots.

Nucleic acids research·2026
Same author

Force-dependent structural dynamics of the giant nesprin-2.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Response to Letter to the Editor on "Higher sexual frequency correlated with lowered PSA complex levels in U.S. men aged 40-59 and without prostate conditions: a nationwide cross-sectional study".

The journal of sexual medicine·2026
Same journal

Proton-Gated Torsional Spring for Molecular Energy Storage.

Journal of the American Chemical Society·2026
Same journal

Topologically Programmed Dual-Channel Covalent Organic Frameworks Decouple Gas and Ion Fluxes for Acidic CO<sub>2</sub> Electroreduction.

Journal of the American Chemical Society·2026
Same journal

Plasmonic Re-Excitation Enables Superoxide-Mediated Ethane Conversion to Acetic Acid under Visible Light.

Journal of the American Chemical Society·2026
Same journal

Photocatalytic Controlled Halodefluorination of Perfluoroalkyl Compounds Using <i>N</i>-Arylphenothiazines.

Journal of the American Chemical Society·2026
Same journal

Photoinduced Disproportionation Enables Oxidative Addition of Aryl Iodides at a Gallium(I) Center.

Journal of the American Chemical Society·2026
Same journal

Biocatalytic C3 β-<i>O</i>-Glycosylation of Triterpenes and Sterols to Synthesize Natural and Unnatural Saponins.

Journal of the American Chemical Society·2026
查看所有相关文章

相关实验视频

Updated: Aug 29, 2025

Biomimetic Materials to Characterize Bacteria-host Interactions
12:22

Biomimetic Materials to Characterize Bacteria-host Interactions

Published on: November 16, 2015

9.5K

细菌粘附复合物的机械稳定

Wenmao Huang1,2, Shimin Le1,3, Yuze Sun2

  • 1Department of Physics, National University of Singapore, Singapore 117542.

Journal of the American Chemical Society
|September 7, 2022
PubMed
概括
此摘要是机器生成的。

由于SdrG-Fgβ复合体中的捕获键动力学,细菌的粘附强度随力增加. 这种机械稳定增强了细菌的发病和适应.

更多相关视频

Introducing Shear Stress in the Study of Bacterial Adhesion
13:28

Introducing Shear Stress in the Study of Bacterial Adhesion

Published on: September 2, 2011

15.9K
Engineering Adherent Bacteria by Creating a Single Synthetic Curli Operon
15:28

Engineering Adherent Bacteria by Creating a Single Synthetic Curli Operon

Published on: November 16, 2012

14.6K

相关实验视频

Last Updated: Aug 29, 2025

Biomimetic Materials to Characterize Bacteria-host Interactions
12:22

Biomimetic Materials to Characterize Bacteria-host Interactions

Published on: November 16, 2015

9.5K
Introducing Shear Stress in the Study of Bacterial Adhesion
13:28

Introducing Shear Stress in the Study of Bacterial Adhesion

Published on: September 2, 2011

15.9K
Engineering Adherent Bacteria by Creating a Single Synthetic Curli Operon
15:28

Engineering Adherent Bacteria by Creating a Single Synthetic Curli Operon

Published on: November 16, 2012

14.6K

科学领域:

  • 微生物学
  • 生物物理
  • 生物化学

背景情况:

  • 格拉姆阳性细菌利用粘附复合体来结合宿主组织.
  • 这些粘合物的拉力是可变的,可以影响结合强度.
  • 之前的研究缺乏在生理上相关力量的粘附力学探测技术.

研究的目的:

  • 研究SD重复蛋白G (SdrG) 和纤维素β (Fgβ) 粘附复合物的捕获键动力学.
  • 在皮科纽顿力下确定细菌粘附的机械性质.
  • 了解机械力量在细菌粘附和发病过程中的作用.

主要方法:

  • 使用超稳定的磁基单分子方法.
  • 在37°C下测量了SdrG-Fgβ复合物的寿命.
  • 分析了粘附复合物的解离路径.

主要成果:

  • SdrG-Fgβ复合体的寿命随着力量的增加而呈指数增长,在30pN时达到1000s.
  • 证明了细菌粘附的机械稳定.
  • 确定SdrG"锁"链的解结为关键解离步骤.
  • 在同类细菌粘附中观察到类似的捕获键动力学.

结论:

  • 细菌粘附表现出捕获-结合动力学,导致力下的机械稳定.
  • 这种依赖力量的增强增强了细菌的附着性,可能对病变产生至关重要.
  • 这些发现表明细菌适应和宿主殖民的一般机制.