肥胖会增加巨细胞的记忆力
Kevin D Mangum1, Katherine A Gallagher1
1Departments of Surgery and Microbiology and Immunology, University of Michigan, Ann Arbor, MI, USA.
Science (New York, N.Y.)
|January 5, 2023
概括
肥胖会改变骨髓细胞中的表观遗传编程, 这项研究突显了代谢健康与眼睛疾病进展之间的新联系.
科学领域:
- 免疫学
- 代谢疾病
- 眼科 眼科
背景情况:
- 肥胖是全球日益严重的健康问题,
- 黄斑退化是导致视力丧失的主要原因,尤其是在老年人群中.
- 新出现的证据表明,炎症和免疫细胞在黄斑变性病变中起作用.
研究的目的:
- 研究肥胖对骨髓细胞表观遗传的影响.
- 确定骨髓细胞中的这些表观遗传变化是否有助于黄斑退化的发展或进展.
- 阐明将代谢功能障碍与眼部病理联系起来的分子机制.
主要方法:
- 使用食诱导肥胖的小鼠模型.
- 在骨髓细胞群中进行单细胞RNA测序和ATAC测序.
- 对视网膜组织进行了组织学和功能测试.
主要成果:
- 肥胖引起了髓状细胞的显著表观遗传变化,包括DNA甲基化和基因组修饰的变化.
- 这些表观遗传修饰与骨髓细胞的基因表达特征的改变有关,促进了亲炎性表型.
- 这些表观遗传变化在骨髓细胞中的实验诱导在体内加剧了斑点退化特征.
- 相反,针对这些表观遗传途径的干预措施改善了疾病的严重程度.
结论:
- 肥胖症中髓状细胞的表观遗传重新编程是黄斑退化的一个关键驱动因素.
- 针对骨髓细胞表观遗传学是与肥胖相关的黄斑变性的一种潜在治疗策略.
- 这项研究揭示了代谢综合征与视网膜退行性疾病之间的新机理联系.
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