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Updated: May 8, 2026

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs
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有针对性的生物分子调控平台:分割和混合的PROTAC方法

Fenfang Yang1, Qinhong Luo1,2, Yuechen Wang1

  • 1State Key Laboratory of Chemical Oncogenomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen 518055, China.

Journal of the American Chemical Society
|March 31, 2023
PubMed
概括

一个新的分离和混合纳米平台简化了针对性RNA降解和蛋白质降解的双功能分子的创建. 这种平台通过分离和混合蛋白质溶解向模拟器 (SM-PROTAC) 进行演示,为各种治疗应用提供可编程控制.

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相关概念视频

Tagging and Fusion Proteins01:24

Tagging and Fusion Proteins

Proteins are involved in several cellular processes and biochemical reactions. Analyzing a specific protein of interest requires it to be isolated from the other proteins in the cell. This is achieved by overexpressing the specific gene in a suitable host to produce large quantities of the target protein. A tag or label is recombined with the gene to produce a fusion protein containing the target protein and the tag. The tags on these fusion proteins can then be used for easy detection and...