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相关概念视频

Hybridoma Technology01:31

Hybridoma Technology

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Hybridoma technology is used for the large-scale production of monoclonal antibodies. Monoclonal antibodies bind to only a single antigenic determinant or epitope. Such antibodies are used in research, diagnostics, and disease therapy. The hybridoma technology established in 1975 by Georges Köhler and Cesar Milstein was awarded the Nobel Prize in Medicine in 1984 for revolutionizing research and therapy.
Hybridoma Selection
Commonly used fusion techniques — electroporation,...
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A High Throughput MHC II Binding Assay for Quantitative Analysis of Peptide Epitopes
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免疫信息学协议设计多位子单位疫苗.

Parismita Kalita1, Aditya K Padhi2, Timir Tripathi1,3

  • 1Molecular and Structural Biophysics Laboratory, Department of Biochemistry, North-Eastern Hill University, Shillong, Meghalaya, India.

Methods in molecular biology (Clifton, N.J.)
|May 31, 2023
PubMed
概括

免疫信息学通过从病原体基因组中识别免疫原来加速疫苗设计. 该协议详细说明了创建多表位子单位疫苗的细节,强调需要对计算设计进行实验室验证.

关键词:
辅助剂 辅助剂 辅助剂停靠对接 停靠对接剧情片 (Epitopes) 是一种表情片.免疫信息学是指免疫信息学.在 silico 疫苗设计中.模拟分子动力学模拟亚单位疫苗 亚单位疫苗

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科学领域:

  • 免疫学 免疫学 免疫学
  • 生物信息学是一种生物信息学.
  • 疫苗开发 疫苗开发

背景情况:

  • 技术的进步使得基因组数据,计算工具和机器学习得到广泛的访问.
  • 免疫信息学已经成为快速设计疫苗候选人的强大领域.

研究的目的:

  • 为设计多表位子单元疫苗提供一个用户友好的协议.
  • 突出免疫信息学在加速疫苗开发中的作用.

主要方法:

  • 使用计算工具和数据库来选病原体基因组.
  • 鉴定用于疫苗配方的高度免疫性或表位.

主要成果:

  • 证明了计算免疫信息学方法在快速设计疫苗候选人的能力.
  • 建立了一个创建多表位子单元疫苗的协议.

结论:

  • 免疫信息学为设计潜在疫苗提供了一种有效的方法.
  • 在计算机设计疫苗临床试验之前,对免疫性和安全性的实验室评估至关重要.