在急性和超急性肝衰竭中使用肝支持技术
Sanjay Chaudhary1, Kianoush B Kashani2,3
1Department of Critical Care Medicine, Mayo Clinic, Jacksonville, Florida, USA.
Contributions to nephrology
|June 1, 2023
概括
外体肝支持 (ECLS) 设备对于肝衰竭患者至关重要,为移植提供了一座桥梁. 本综述详细介绍了当前ECLS技术及其临床影响.
科学领域:
- 生物医学工程 生物医学工程
- 肝病学 肝病学是一种肝病学.
- 再生医学是一种再生医学.
背景情况:
- 急性肝衰竭和急性-慢性肝衰竭的发病率增加,需要先进的治疗选择.
- 移植供体肝脏的有限可用性造成了对替代性肝脏支持策略的迫切需要.
- 身体外肝支持 (ECLS) 旨在将患者连接到移植或作为目的地治疗.
研究的目的:
- 审查当前体外肝支持器件 (ECLS) 的现状.
- 分析各种ECLS技术相关的基于证据的数据.
- 概述将患者连接到肝移植或提供替代疗法的设备.
主要方法:
- 对ECLS设备的现有文献和临床数据的审查.
- 基于其支持机制的ECLS设备的分类 (例如,脏替代疗法,白蛋白透析,血酶,基于肝细胞的系统).
- 评估不同ECLS方法的临床结果和影响.
主要成果:
- 已经开发了多种ECLS设备,从简单的支持系统到复杂的生物人工设备.
- 技术包括白蛋白透析 (例如,普罗米修斯,分子吸附剂循环系统),高容量血合成和基于肝细胞的系统.
- 这些设备的临床影响和有效性各不相同,突显了需要进一步的研究和开发.
结论:
- 对于肝衰竭患者来说,ECLS是一个重要的治疗策略,它解决了器官需求和供应之间的差距.
- 持续的ECLS技术创新对于改善患者的治疗结果和扩大治疗可能性至关重要.
- 对当前ECLS设备及其证据基础的全面了解对于临床决策至关重要.
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