维生素E摄入量和偏氧酶1 (
Quynh-Anh Bui1, Madhawa Gunathilake2, Jeonghee Lee2
1Department of Cancer Control and Population Health, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang-si, Gyeonggi-do, South Korea.
International journal of food sciences and nutrition
|June 7, 2023
概括
更高的维生素E摄入量与降低结直肠癌 (CRC) 风险有关. 这种效应在具有偏氧酶1 (PON1) rs662多态的CC基因型的个体中得到放大.
科学领域:
- 在瘤学瘤学.
- 营养科学 营养科学
- 遗传学 遗传学 是一个
背景情况:
- 维生素E和偏氧酶1 (PON1) 与癌症的发展有关.
- 维生素E和PON1对结直肠癌 (CRC) 风险的相互作用作用需要进一步研究.
研究的目的:
- 检查维生素E摄入量与CRC风险之间的关联.
- 调查维生素E摄入量与PON1rs662多态性与CRC风险相关的相互作用.
主要方法:
- 研究人员对1351名CRC患者和2670名对照进行了病例控制研究.
- 收集了有关维生素E摄入量和PON1 rs662多态性的数据.
- 进行了统计分析,包括赔率比率 (OR) 和95%置信区间 (CI).
主要成果:
- 在维生素E摄入量和CRC风险之间发现了不良关联 (OR = 0.31;95% CI = 0.22-0.42).
- 与T等位基因携带者 (OR = 0.74;95% CI = 0.61-0.90) 相比,在具有PON1 rs662多态的CC基因型的个体中观察到较低的CRC风险.
- 维生素E摄入量与PON1 rs662变体之间的显著相互作用,特别是在具有CC基因型的受试者中 (p-相互作用=0.014).
结论:
- 摄入维生素E与CRC的几率较低有关.
- 维生素E对CRC的保护作用在携带PON1rs662多态的C等位基因的个体中得到增强.
相关概念视频
Peroxisomes
13.7K
Peroxisomes are specialized organelles present in fungi, plant, and animal cells. It can vary in number, size, morphology, and activity depending on the type of tissue and the nutritional state of the cell. For example, cells with active lipid metabolism, such as adipocytes, neurons, and hepatocytes, have more peroxisomes than other cells in the body. Besides their primary role in breaking down complex organic molecules, peroxisomes can also synthesize specific macromolecules and participate in...
13.7K
Oxidation of Phenols to Quinones
3.2K
In the presence of oxidizing agents, phenols are oxidized to quinones. Quinones can be easily reduced back to phenols using mild reducing agents. The electron-donating hydroxyl group enhances the reactivity of the aromatic ring, enabling oxidation of the ring even in the absence of an α hydrogen.
o-hydroxy phenols are oxidized to o-quinones and p-hydroxy phenols to p-quinones. Such redox reactions involve the transfer of two electrons and two protons. The reversible redox...
o-hydroxy phenols are oxidized to o-quinones and p-hydroxy phenols to p-quinones. Such redox reactions involve the transfer of two electrons and two protons. The reversible redox...
3.2K
Radical Autoxidation
2.2K
The oxidation of an organic compound in the presence of air or oxygen is called autoxidation. For example, cumene reacts with oxygen to form hydroperoxide. Autoxidation involves initiation, propagation, and termination steps. Many organic compounds are susceptible to autoxidation—especially ethers in the presence of oxygen, which form hydroperoxides. Even though this reaction is slow, old ether bottles contain small amounts of peroxide, which leads to laboratory explosions during ether...
2.2K
Protein Import into the Peroxisomes
3.6K
Cells contain membrane-bound organelles called peroxisomes that oxidize organic molecules by transferring hydrogen atoms to oxygen, producing hydrogen peroxide. Peroxisomes enzymatically convert the released hydrogen peroxide into water and oxygen.
Peroxisomal Protein Import:
Peroxisomes lack the genetic machinery required to code for their own proteins. Hence, most peroxisomal membrane, lumenal and transmembrane proteins are synthesized in the cytoplasm or ER and transported to the peroxisome...
Peroxisomal Protein Import:
Peroxisomes lack the genetic machinery required to code for their own proteins. Hence, most peroxisomal membrane, lumenal and transmembrane proteins are synthesized in the cytoplasm or ER and transported to the peroxisome...
3.6K
Autoxidation of Ethers to Peroxides and Hydroperoxides
7.8K
Ethers represent a class of chemical compounds that become more dangerous with prolonged storage because they tend to form explosive peroxides when standing in the air. Autoxidation is the spontaneous oxidation of a compound in air. In the presence of oxygen, ethers slowly oxidize to form hydroperoxides and dialkyl peroxides.
7.8K
Peroxisomes and Mitochondria
87.5K
Peroxisomes and mitochondria are two important oxygen-utilizing organelles in eukaryotic cells. Mitochondria carry out cellular respiration—the process that converts energy from food into ATP. Peroxisomes carry out a variety of functions, primarily breaking down different substances, such as fatty acids.
The peroxisome is a single membrane-bound cellular organelle that can perform several different functions, including lipid metabolism and chemical detoxification. The enzymes within...
The peroxisome is a single membrane-bound cellular organelle that can perform several different functions, including lipid metabolism and chemical detoxification. The enzymes within...
87.5K


