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相关概念视频

Protein Complex Assembly02:41

Protein Complex Assembly

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Proteins can form homomeric complexes with another unit of the same protein or heteromeric complexes with different types.  Most protein complexes self-assemble spontaneously via ordered pathways, while some proteins need assembly factors that guide their proper assembly. Despite the crowded intracellular environment, proteins usually interact with their correct partners and form functional complexes.
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Protein Organization01:13

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Assembly of Cytoskeletal Filaments01:18

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Cytoskeletal filaments are polymeric forms of smaller protein subunits. However, individual cytoskeletal filaments may easily disassemble or associate with other similar filaments to form rigid structures. Microfilaments, made of actin monomers, rely on actin-binding proteins to form bundles and create networks of individual actin filaments. Microtubules rely on microtubule-associated proteins (MAPs) to form sturdy cylindrical structures. However, the proteins involved in forming complex...
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Genome Annotation and Assembly03:36

Genome Annotation and Assembly

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The genome refers to all of the genetic material in an organism. It can range from a few million base pairs in microbial cells to several billion base pairs in many eukaryotic organisms. Genome assembly refers to the process of taking the DNA sequencing data and putting it all back together in a correct order to create a close representation of the original genome. This is followed by the identification of functional elements on the newly assembled genome, a process called genome annotation.
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Protein and Protein Structure02:15

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Proteins are one of the most abundant organic molecules in living systems and have the most diverse range of functions of all macromolecules. Proteins may be structural, regulatory, contractile, or protective. They may serve in transport, storage, or membranes; or they may be toxins or enzymes. Their structures, like their functions, vary greatly. They are all, however, amino acid polymers arranged in a linear sequence.
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相关实验视频

Updated: Jul 27, 2025

A Protocol for Computer-Based Protein Structure and Function Prediction
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A Protocol for Computer-Based Protein Structure and Function Prediction

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使用组合组合算法和AlphaFold2预测大型蛋白质组合的结构.

Ben Shor1, Dina Schneidman-Duhovny1

  • 1The Rachel and Selim Benin School of Computer Science and Engineering, The Hebrew University of Jerusalem, Jerusalem, Israel.

bioRxiv : the preprint server for biology
|June 9, 2023
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概括
此摘要是机器生成的。

使用层次组装算法,CombFold可以准确地预测大型蛋白质复杂结构. 与现有数据库相比,这种方法改善了结构覆盖范围,有助于研究复杂的生物组合.

科学领域:

  • 结构生物学是结构生物学.
  • 计算生物学是一种计算生物学.

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Application of I TASSER, trRosetta, UCSF Chimera, HADDOCK server, and HEX loria for De Novo and In Silico Design of Proteins
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  • 生物化学 生物化学

    • 背景情况:

    • 准确的蛋白质结构预测对于理解生物功能至关重要.
    • 像AlphaFold2这样的现有深度学习模型在单质蛋白质预测方面表现出色,但与大型的多子单元复合体作斗争.
    • 由于它们的规模和复杂的子单元相互作用,预测大型蛋白质复合物的结构仍然是一个重大挑战.

    结论:

    • 在预测大型蛋白质复合物的结构方面,CombFold提供了显著的进步.
    • 它的准确性和整合实验数据的能力提高了它在结构生物学研究中的实用性.
    • 这种工具有望扩大蛋白质组合的结构覆盖范围,超越单个蛋白质.