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Updated: Jul 27, 2025

Generating De Novo Antigen-specific Human T Cell Receptors by Retroviral Transduction of Centric Hemichain
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神经网络模型用于基于序列的TCR和HLA协会预测

Si Liu1, Philip Bradley1,2,3, Wei Sun1,3,4,5

  • 1Public Health Science Division, Fred Hutchinson Cancer Center, Seattle, USA.

bioRxiv : the preprint server for biology
|June 9, 2023
PubMed
概括

T细胞受体 (TCR) 和人类白细胞抗原 (HLA) 的关联对于理解免疫活性至关重要. 一种新的深度学习方法DePTH预测了这些关联,并揭示了与免疫治疗后癌症患者生存相关的HLA相似性.

关键词:
T细胞受体受体的 T 细胞受体.氨基酸序列中的氨基酸序列.人类白细胞抗原.免疫检查点封锁封锁神经网络的神经网络的神经网络

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T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
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Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
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