[尿路感染,包括肺炎炎]
1Klinik für Urologie, Kinderurologie und Andrologie, Justus-Liebig-Universität Giessen, Rudolf-Buchheim Str. 7, 35392, Giessen, Deutschland. florian.wagenlehner@chiru.med.uni-giessen.de.
Medizinische Klinik, Intensivmedizin und Notfallmedizin
|June 16, 2023
概括
尿路感染 (UTI) 的严重程度正在增加. 新抗生素对于对抗导致严重尿路感染的多药耐药细菌和改善患者结果至关重要.
科学领域:
- 传染性疾病 传染性疾病
- 微生物学 微生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 尿路感染 (UTI) 是全球严重的健康负担,其临床表现不同,从不复杂的感染到严重的尿路感染.
- 严重的尿路感染发病率的令人担忧的上升与败血症率的普遍下降形成鲜明对比,突出显示了复杂的尿路感染的不断升级的威胁.
- 现有的尿路感染分类在临床和监管环境之间存在差异,需要标准化的方法来有效管理和研究.
研究的目的:
- 解决对涉及严重尿路感染的多药耐药病原体的新型治疗策略的迫切需要.
- 评估新的抗生素剂和组合剂的疗效,特别针对在尿路感染治疗中的多耐药格拉姆阴性细菌.
- 完善临床研究终点和以患者为中心的评估策略,以评估新抗生素相对于传统治疗方法的比较优势.
主要方法:
- 审查最近的临床研究和有关尿路感染的分类和管理的监管指南.
- 对新兴抗生素研究的分析侧重于对抗在尿路感染中常见的多药耐药格兰氏阴性病原体.
- 开发和应用以患者为中心的结果措施,用于评估新的尿路感染疗法的临床试验.
主要成果:
- 鉴定了多抗药性肠道细菌在严重尿路感染中构成的日益严重的挑战,有助于增加死亡率.
- 研究几种新的抗生素/组合疗法,证明它们对多抗性格拉姆阴性细菌具有特别的疗效.
- 在确定适当的临床终点和以患者为中心的评估策略方面取得进展,以开发尿路感染药物.
结论:
- 新抗生素的开发对于应对由多药耐药细菌驱动的严重尿路感染的发病率上升至关重要.
- 新型抗生素剂和组合在治疗由具有挑战性的阴性病原体引起的尿路感染方面表现有前途.
- 改进的临床试验方法,包括以患者为中心的终点,对于证明新的尿路感染治疗的价值至关重要.
相关概念视频
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01:27Acute Pyelonephritis I: Introduction
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01:25Urinary Tract Infection II: Pathophysiology
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01:30Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care
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01:28Acute Pyelonephritis II: Diagnostic Studies and Management
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Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
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