天生的免疫反应产生组织特异性的瓶,随着病原体的剂量而变大
Karthik Hullahalli1, Katherine G Dailey1, Matthew K Waldor1
1Department of Microbiology, Harvard Medical School, Boston, MA 02115; Division of Infectious Diseases, Brigham & Women's Hospital, Boston, MA 02115.
bioRxiv : the preprint server for biology
|June 19, 2023
概括
病原体剂量影响免疫屏障,揭示了"剂量缩放",其中免疫反应的有效性随着细菌负载的变化而变化. 这一发现为了解感染结果提供了一个新的框架.
科学领域:
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
- 传染性疾病 传染性疾病
背景情况:
- 病原体必须克服宿主免疫系统的瓶,才能引起感染.
- 感染瓶通过限制病原体注射来决定疾病的结果.
- 了解这些瓶对于量化免疫屏障的有效性至关重要.
结论:
- 剂量调整量化地将天生的免疫与感染瓶联系起来.
- 这一框架为我们提供了关于病原体注射剂大小如何影响感染结果的新理解.
- 强调了感染性疾病中免疫反应的复杂性和剂量依赖性.
相关概念视频
Introduction to Innate and Adaptive Immunity
4.2K
The human immune system is a complex defense mechanism that protects the body from harmful pathogens and foreign substances. It comprises two crucial components: innate and adaptive immunity.
Innate immunity is the body's natural, nonspecific defense system that acts quickly to protect against pathogens. It incorporates physical barriers like skin and mucous membranes and cellular elements such as phagocytes and natural killer cells. This part of our immune system provides an immediate,...
Innate immunity is the body's natural, nonspecific defense system that acts quickly to protect against pathogens. It incorporates physical barriers like skin and mucous membranes and cellular elements such as phagocytes and natural killer cells. This part of our immune system provides an immediate,...
4.2K
Defense Against Bacterial Pathogens
1.5K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
1.5K
Cell-mediated Immune Responses
69.1K
Overview
69.1K
Immune Response Against Viral Pathogens
830
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
830
What is the Immune System?
112.1K
Overview
112.1K
Cells of the Adaptive Immune Response
1.1K
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
1.1K


