诊断成像中的观察者间变异性研究:一种方法学系统性审查
Laura Quinn1,2, Konstantinos Tryposkiadis1,2, Jon Deeks1,2
1Test Evaluation Research Group, Institute of Applied Health Research, University of Birmingham, Birmingham, United Kingdom.
The British journal of radiology
|July 3, 2023
概括
观察者间变异性研究往往缺乏合理的样本大小,其结论可能与报告的统计指标如类内相关系数 (ICC) 或卡帕 (κ) 不一致. 许多使用静态图像的研究在偏差评估方面存在局限性.
科学领域:
- 医疗成像医学成像
- 研究方法研究方法研究方法学
- 统计分析 统计分析
背景情况:
- 观察者间的变性对于评估诊断测试的可靠性至关重要.
- 进行和报告这些研究的现行做法需要进行批判性评估.
- 了解方法限制是提高研究质量的关键.
研究的目的:
- 审查观察者间可变性研究的方法.
- 评估当前的实践以及进行和报告这些研究的质量.
- 确定研究设计和分析需要改进的领域.
主要方法:
- 2019年1月至2020年1月期间发表的观察者间变异性研究的系统审查.
- 数据提取包括研究特征,种群,可变性测量和结果.
- 使用COSMIN工具对可靠性和测量错误进行了偏差风险评估.
主要成果:
- 包括79项研究,中位数为47名患者和4名观察员.
- 样本大小往往很小,在大多数研究中都缺乏理由.
- 类内相关系数 (ICC) 和卡帕 (κ) 统计数据是常见的,但结论有时与结果相矛盾.
- 许多使用静态图像的研究得到了充分的评分,但没有适用的偏差评估标准.
结论:
- 观察者间变异性研究显示出不同的设计和方法需要进一步评估.
- 小的,不合理的样本大小和统计结果和研究结论之间的差异是普遍存在的.
- 方法上的局限性,特别是静态图像,影响了可靠性和测量误差的评估.
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