皮层形态的差异和孩子的内化或外化问题:解释共发生的情况
Yingzhe Zhang1, Bing Xu2, Hannah H Kim3
1Department of Epidemiology Harvard T.H. Chan School of Public Health Boston Massachusetts USA.
JCPP advances
|July 11, 2023
概括
儿童内化和外化问题显示出与皮质体积的对立的全球关联. 这些效应只有在将两种问题类型一起考虑时才会显现出来,这凸显了在神经成像研究中考虑共发生的重要性.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 儿童精神病学 儿童精神病学
背景情况:
- 童年内化和外化问题经常同时发生,但很少有研究一起检查它们的神经相关性.
- 以前的研究往往集中在一个问题类型上,忽视了内部化和外部化行为之间的复杂相互作用.
研究的目的:
- 调查与童年内化和外化问题相关的特定皮质基质,解释它们的共同发生.
- 为了澄清皮层形态学与青春期前儿童的不同行为问题类型之间的关系.
主要方法:
- 利用了来自青少年大脑认知发展研究的9635名儿童 (9-11岁) 的数据.
- 通过使用儿童行为检查表和FreeSurfer的标准化皮质卷来评估内部化和外部化问题的得分.
- 采用多变量线性回归和双因素模型来检查关联,调整共变量和总大脑体积 (TBV).
主要成果:
- 单独的分析显示,与外部化和内部化问题相关的皮质体积较小.
- 在计算共发生时,内部化问题与较大的皮质体积有关,而外部化问题仍然与较小的体积有关.
- 关联似乎是全球效应,在对TBV进行调整后,大多数变得无关紧要.
结论:
- 儿童内化和外化问题与皮层形态学具有全球对立的,非特定的关联.
- 这些相反的关联只有在分析中考虑内部化和外部化问题的同时发生时才明显.
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