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相关概念视频

Protein Folding01:22

Protein Folding

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Overview
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Globular and Fibrous Proteins02:21

Globular and Fibrous Proteins

43.8K
Many proteins can be classified into two distinct subtypes - globular or fibrous. These two types differ in their shapes and solubilities.
Globular proteins are also known as spheroproteins and typically are approximately round in shape. They contain a mix of amino acid types and contain differing sequences in their primary structures. Globular proteins have many different functions, such as enzymes, cellular messengers, and molecular transporters. These roles often require the proteins to be...
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Protein and Protein Structure02:15

Protein and Protein Structure

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Proteins are one of the most abundant organic molecules in living systems and have the most diverse range of functions of all macromolecules. Proteins may be structural, regulatory, contractile, or protective. They may serve in transport, storage, or membranes; or they may be toxins or enzymes. Their structures, like their functions, vary greatly. They are all, however, amino acid polymers arranged in a linear sequence.
A protein's shape is critical to its function. For example, an enzyme...
79.8K
Conservation of Protein Domains Over Different Proteins02:26

Conservation of Protein Domains Over Different Proteins

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Protein domains are small structurally independent units that are part of a single amino acid chain.  Although these domains are often structurally independent, they may rely on synergistic effects to perform their functions as part of a larger protein. Protein domains may be conserved within the same organism, as well as across different organisms.
A limited set of protein domains often duplicate and recombine during evolution. These domains can be organized in different combinations to...
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Fibrous Proteins00:55

Fibrous Proteins

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Fibrous proteins are either long and narrow proteins or assemble to form long and thin structures. They contain repetitive units and usually consist of either alpha helices or beta sheets and, in rare cases, a mix of both. The amino acids in the primary structure often consist of repeating amino acid sequences. The role of fibrous proteins is primarily structural. Many are located in the extracellular matrix and are present in connective tissues to impart strength and joint mobility. They are...
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Globular Proteins01:27

Globular Proteins

7.5K
In organisms, proteins are the most abundant macromolecules. They act as the building blocks of life and play various crucial roles in the body. Proteins can be broadly classified into two distinct subtypes based on their shape and solubilities: globular proteins and fibrous proteins.
Globular proteins serve many important physiological functions, such as acting as enzymes, cellular messengers, and molecular transporters. These roles often require the proteins to be soluble in the aqueous...
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Microfluidic Mixers for Studying Protein Folding
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流体蛋白质折叠空间及其影响

Lauren L Porter1,2

  • 1National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland, USA.

BioEssays : news and reviews in molecular, cellular and developmental biology
|July 11, 2023
PubMed
概括

蛋白质折叠空间不是离散的,而是流动的,因为折叠切换蛋白质可以根据细胞信号改变结构和功能. 这挑战了长期以来的观点,并扩大了我们对蛋白质多样性的理解.

科学领域:

  • 生物化学 生物化学
  • 结构生物学 结构生物学
  • 分子生物学分子生物学

背景情况:

  • 传统上,蛋白质折叠空间被认为是离散的,有不同的序列编码不同的蛋白质折叠.
  • 实验证据表明,氨基酸序列和蛋白质结构之间存在静态关系.

研究的目的:

  • 挑战离散蛋白质折叠空间的概念.
  • 引入和支持流体蛋白质折叠空间的概念.
  • 探索折叠切换蛋白对蛋白质多样性的影响.

主要方法:

  • 审查和综合最近的实验观测支持折叠切换.
  • 分析折叠切换对蛋白质序列结构关系的影响.

主要成果:

  • 折叠切换蛋白质表明蛋白质折叠空间是流动的,而不是离散的.
  • 氨基酸序列可以在具有明显二次结构的折叠之间相互转换.
  • 折叠切换是进化选择,表明功能优势.

结论:

  • 微小的序列修改可以显著改变蛋白质的结构和功能.
  • 诸如替代拼接和翻译后修改等机制可以扩大蛋白质组的多样性.
关键词:
另一个替代拼接方法是拼接.变形蛋白质是一种变形蛋白质.蛋白质的进化 蛋白质的进化蛋白质折叠切换 切换蛋白质折叠蛋白质折叠 蛋白质的折叠

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  • 发现折叠切换蛋白质需要对蛋白质结构和进化进行修订.