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相关概念视频

Neurulation01:30

Neurulation

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Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the...
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2D and 3D Human Induced Pluripotent Stem Cell-Based Models to Dissect Primary Cilium Involvement during Neocortical Development
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2D and 3D Human Induced Pluripotent Stem Cell-Based Models to Dissect Primary Cilium Involvement during Neocortical Development

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HNRNPU的多任务处理对于正确的皮质发育至关重要.

Tamar Sapir1, Orly Reiner1

  • 1Weizmann Institute of Science, Molecular Genetics and Molecular Neuroscience, Rehovot, Central, Israel.

BioEssays : news and reviews in molecular, cellular and developmental biology
|July 13, 2023
PubMed
概括

异质核核糖核蛋白U (HNRNPU) 功能丧失会导致神经细胞死亡和基因表达失调,从而导致神经发育障碍. 这会影响大脑的发育和完整性.

科学领域:

  • 分子生物学分子生物学
  • 神经科学是一个神经科学.
  • 遗传学 遗传学 是一个

背景情况:

  • 异质核核核糖核蛋白U (HNRNPU) 对于RNA剪接,染色体组织和基因表达至关重要.
  • HNRNPU/脚手架附着因子A (SAF-A) 活动对于DNA复制,基因组完整性和线粒体忠实性至关重要.
  • 适当的HNRNPU功能对于人类大脑强壮发育至关重要.

研究的目的:

  • 研究HNRNPU在神经发育过程中的作用.
  • 了解HNRNPU功能丧失的细胞和分子后果.
  • 阐明与HNRNPU相关的神经发育障碍 (HNRNPU-NDD) 背后的机制.

主要方法:

  • 细胞测试以评估神经前代细胞和神经转移后神经元的活力.
  • 对HNRNPU缺乏细胞中的基因表达和替代拼接模式的分析.
  • 对受影响的信号通路进行生物信息分析.

主要成果:

  • 丧失HNRNPU功能导致神经前体细胞和神经转移后神经元的死亡,前体细胞的敏感性更高.
  • 由于HNRNPU的切断,导致基因表达失调和替代拼接.
  • 受影响的基因汇聚在涉及HNRNPU-NDD病理的信号通路上.
关键词:
灭症 (apoptosis) 是一种死亡的过程.大脑发育大脑的发育大脑的发展发育延迟的发展延迟.不同质的核核核糖核蛋白U.智力障碍 智力障碍是一种智力障碍.神经原始体的神经祖先神经发育障碍是一种神经发育障碍.脚手架的附着因子 A 拼接

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结论:

  • HNRNPU对于神经细胞的生存和正常的大脑发育至关重要.
  • 在HNRNPU功能中的缺陷通过细胞和分子干扰导致神经发育障碍.
  • 了解HNRNPU的作用可以了解HNRNPU-NDD的分子基础.