结构修改赋予具有多面性功能的小分子SN38衍生物

Yi Dai1,2, Meng Qian1, Yan Li1

  • 1College of Pharmaceutical Science, Anhui Xinhua University, Hefei 230088, China.

PubMed
概括

结构修改7-乙基-10-基坎普托丁 (SN38),一个强大的拓酶I抑制剂,对于增强其抗癌性质至关重要. 研究重点是改善可溶性,活性和减少毒性,以改善药物开发.

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