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定义NAD (P) (H) 催化剂的作用
Jyothi Dhuguru1, Ryan W Dellinger2, Marie E Migaud1
1Department of Pharmacology, Mitchell Cancer Institute, College of Medicine, University of South Alabama, 1660 Springhill Avenue, Mobile, AL 36604, USA.
Nutrients
|July 14, 2023
概括
食维生素B3补充剂旨在提高尼古丁胺氨酸二核酸 (NAD+) 水平,随着年龄的增长而下降. 本综述考察了NAD+分解产物,强调了它们在理解补充剂有效性和潜在健康影响方面的重要性.
科学领域:
- 生物化学和新陈代谢
- 衰老和疾病研究研究
- 营养科学 营养科学
背景情况:
- 像尼古丁胺和尼古丁酸这样的食维生素B3成分是必不可少的氧化还原配因子尼古丁胺氨基二核酸 (NAD+) 的前体.
- 观察到NAD+水平随着年龄的增长和各种疾病状态而下降.
- 使用NAD+生物合成中间体的补充策略,如尼古丁胺基因 рибоoside (NR) 和尼古丁胺基因 mononucleotide (NMN),旨在恢复NAD+水平.
研究的目的:
- 审查已知和新出现的NAD (H) 代谢组的催化剂.
- 突出这些催化剂的生化和生理功能.
- 强调需要分析方法来评估完整的NAD (H) 代谢组.
主要方法:
- 关于NAD+前体及其代谢物研究的文献综述.
- 对参与NAD (H) 形成和分解的生物化学途径的分析.
- 讨论量化NAD (H) 代谢组的分析挑战.
主要成果:
- 补充NAD+前体会改变NAD (H) 的代谢概况.
- 在NAD (H) 催化剂的分布和丰度根据前体,物种和组织而有很大差异.
- 某些NAD (H) 催化剂可能作为生理障碍的生物标志物,并且可能不是惰性的.
结论:
- 对于NAD (H) 催化剂的药理学意义往往被忽视.
- 了解NAD (H) 代谢物概况对于评估NAD+前体补充剂的有效性和安全性至关重要.
- 需要全面的分析方法来充分描述NAD (H) 代谢组及其对健康和疾病的影响.
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