为创伤而设计的静脉内疗法
Trey J Pichon1,2, Nathan J White3,2, Suzie H Pun1,2
1Department of Bioengineering and Molecular Engineering and Sciences Institute, University of Washington, 3720 15 Avenue NE, Box 355061, Seattle, Washington 98105, United States.
Current opinion in biomedical engineering
|July 17, 2023
概括
严重的出血和冲击需要快速干预. 新的低容量复苏剂 (LVR) 显示出逆转出血性休克的前景,解决创伤患者的临界医院前护理缺口.
科学领域:
- 生物医学工程 生物医学工程
- 创伤护理 创伤护理
- 药理学 药理学是指药理学的学科.
背景情况:
- 创伤引起的出血和休克是时间关键的紧急情况,通常会在几个小时内导致死亡.
- 预医院运输延误,特别是在低至中等收入国家,需要有效的干预措施来控制出血和管理休克.
- 现有的第一代静脉静脉血静止剂在临床翻译方面面临挑战,尽管药物输送平台的进步.
研究的目的:
- 审查从临床前到临床环境转化静脉静脉血压治疗的挑战.
- 讨论出血性休克的生理机制.
- 引入和评估一种新的低体积复苏剂 (LVR),PEG-20k,以潜在的临床应用.
主要方法:
- 关于第一代血静止器及其翻译挑战的文献综述.
- 出血性休克的生理概述. 出血性休克的生理概述.
- 突出并讨论一种新的低容量复苏剂 (LVR) - - PEG-20k.的特性.
主要成果:
- 很少有血液静止疗法通过大型动物临床前评估取得进展,没有一种疗法达到临床应用.
- 了解出血性休克生理学对于开发有效的治疗方法至关重要.
- PEG-20k被描述为一个有前途的新型低容量复苏剂.
结论:
- 在将先进的静血剂转化为临床实践中存在重大障碍.
- 有效管理出血性休克需要解决出血控制和体积复苏.
- 合理设计原则对于开发下一代创伤患者低容量复苏剂至关重要.
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