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Updated: Jul 23, 2025

Author Spotlight: Investigating the Motion Dynamics of the Eukaryotic Replisome Components at the Single-Molecule Level
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改变蛋白质-DNA相互作用在复制起源许可期间促进ORC结合位点交换.

Annie Zhang1,2, Larry J Friedman3, Jeff Gelles3

  • 1HHMI, Cambridge, MA 02139.

Proceedings of the National Academy of Sciences of the United States of America
|July 18, 2023
PubMed
概括

原始识别复合体 (ORC) 通过切换结合点来加载两个Mcm2-7,用于通过切换结合点来进行DNA复制. DNA 不曲和滑动有助于ORC释放,使得序列酶加载和双向复制成为可能.

关键词:
启动DNA复制的开始麦克米2 - 7直化酶原产地许可证的原产地许可证.原产地识别复合体 (ORC) 是一个复合体.单分子FRETET是一种单分子FRET.

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