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相关概念视频

Factors Influencing Drug Absorption: Pharmaceutical Parameters01:28

Factors Influencing Drug Absorption: Pharmaceutical Parameters

154
Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
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通过选方法开发和评估febuxostat固体分散.

Jeong Sun Sohn1, Jin-Seok Choi2

  • 1College of General Education, Chosun University, Gwangju 61452, Republic of Korea.

Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society
|August 10, 2023
PubMed
概括

这项研究开发了一种新的Febuxostat固体分散 (SD) 配方,以提高药物的溶解性和溶解性. 优化的Febux-SD配方在体外药物释放中显著改善,预计将增加生物可用性.

关键词:
溶解 (%) 的时间.这是一种Febuxostat.在体外的药物释放.在体外的透性.梅格卢米内 (Meglumine) 是一个闪亮的光线.稳定的稳定性 稳定的稳定性

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科学领域:

  • 制药科学 制药科学
  • 药物输送系统 药物输送系统

背景情况:

  • 费布克索斯塔特是一种BCSII类药物,具有较差的水溶性,限制了其治疗疗效.
  • 提高Febuxostat的溶解性和溶解性对于改善其生物利用性至关重要.

研究的目的:

  • 开发一种改进的Febuxostat配方,使用选方法增加体外溶解和药物释放.
  • 为了研究固体分散技术对于Febuxostat溶解的潜力.

主要方法:

  • 采用选方法来选择最佳的溶解剂,pH剂和载体.
  • 用于制备Febuxostat-SD配方,使用了溶剂蒸发方法.
  • 进行了体外溶解,药物释放和透性研究,并与商用Feburic®片进行了比较.

主要成果:

  • 与Feburic®相比,最佳的Febuxostat-SD配方 (SD3) 在各种pH条件下显示出明显更高的溶解率.
  • 在实验室中,SD3配方的药物释放和透性明显改善.
  • SD3配方在6个月的时间内表现出良好的稳定性,物理化学性能发生了变化.

结论:

  • 通过使用美格胺成功开发了一种新的Febuxostat-SD配方.
  • 在随后的动物和人类研究中,Febuxostat-SD配方的增强溶解概况表明了改善体内生物可用性的潜力.