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相关概念视频

Tension Response at Adherens Junctions01:26

Tension Response at Adherens Junctions

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The adherens junctions that anchor cells together are multi-protein complexes that dynamically adapt to mechanical stimuli such as tensile forces and shear stress. Mechanosensory proteins in these junctions can sense such mechanical stimuli and undergo a shift in their conformation, resulting in an altered function — a process called mechanotransduction.
α-Catenin as a Mechanosensory Protein
The α-catenin of adherens junctions is an allosteric protein with three VH (vinculin...
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Cell-matrix's Response to Mechanical Forces01:13

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In animal cells, the extracellular matrix allows cells within tissues to withstand external stresses and transmits signals from the outside of the cell to the inside. The extracellular matrix is extensive, and its composition varies between different types of tissues. For example, the reticular fibers and ground substance make up the ECM in loose connective tissue, while collagen and bone minerals make up the ECM of bone tissue. 
Anchoring junctions mechanically attach a cell to the...
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在引力显微镜和组织收缩之间的计算桥梁.

Shannon M Flanary1, Seokwon Jo2, Rohit Ravichandran1

  • 1Department of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, Minnesota 55455, USA.

Journal of applied physics
|August 18, 2023
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概括
此摘要是机器生成的。

一个新的多尺度模型将细胞力学与动脉中的组织反应联系起来. 这个框架有助于预测血管疾病,并开发针对平滑肌肉细胞功能障碍的向疗法.

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科学领域:

  • 生物医学工程 生物医学工程
  • 机械生物学 机械生物学
  • 计算生物学 计算生物学

背景情况:

  • 动脉壁机制取决于光滑肌肉细胞 (SMC) 的收缩性.
  • 细胞对刺激的反应可能与组织水平的观察不同.
  • 了解这种尺度差异对于疾病研究至关重要.

研究的目的:

  • 开发一个连接微观SMC信号与宏观动脉力学的多尺度模型.
  • 创建适用于各种生理和病理条件的灵活框架.
  • 为了弥合细胞和组织水平的收缩现象之间的差距.

主要方法:

  • 一个综合生化信号和光纤网络机制的多尺度计算模型.
  • 微 (细胞) 和宏 (组织) 系统的分析.
  • 适用于体外引力显微镜和体外同位数收缩实验.

主要成果:

  • 该模型预测活跃收缩性在中间应变时独立于拉伸.
  • 它准确地模拟了细胞规模和组织规模的收缩性.
  • 该模型复制了实验观察到的行为,包括高血糖引起的超收缩性.

结论:

  • 多尺度模型有效地将细胞尺度机制转化为组织尺度的表型.
  • 这个框架可以利用现有的细胞数据来了解血管疾病.
  • 它为开发新的平滑肌肉细胞向疗法提供了潜力.