口腔微生物组和早产婴儿
Marijana Vidmar Šimic1, Aleš Maver2,3, Ana Nyasha Zimani2
1Division of Obstetrics and Gynecology, Department of Perinatology, University Medical Centre Ljubljana, Ljubljana, Slovenia.
Frontiers in medicine
|August 23, 2023
概括
母亲口腔微生物组的变化,特别是Veillonella,Prevotella和Capnocytophaga的水平增加,与早产 (PTB) 有关. 需要进一步的研究来澄清这些细菌在PTB病因学中的作用.
科学领域:
- 微生物学 微生物学
- 产科 产科 产科 产科 产科
- 基因组学就是基因组学.
背景情况:
- 过早分娩 (PTB) 的原因是复杂的,并未完全理解.
- 孕产妇牙周病是怀孕不良结果的已知风险因素,但特定的致病因子仍未确定.
- 研究正在探索整个口腔微生物组在PTB中的作用.
研究的目的:
- 调查口腔微生物组合和PTB之间的关联.
- 为了比较患有PTB的妇女的口腔微生物组与产期妇女 (TB) 的口腔微生物组.
主要方法:
- 一项涉及152名高加索孕妇 (61名PTB,91名TB) 的病例控制研究.
- 采集并使用16S rRNA基因测序 (V3-V4区域) 分析了口腔拭子样本.
- 排除标准包括其他主要的医疗或产科疾病.
主要成果:
- 在所有参与者中,占主导地位的细菌系是Firmicutes,Proteobacteria,Bacteroidetes,Fusobacteria和Actinobacteria.
- 在PTB群体中,坚果菌和细菌菌更为丰富,而蛋白质菌的流行率较低.
- 在PTB组中,Veillonella,Prevotella和Capnocytophaga种类的含量增加,而Veillonella massillensis的含量增加.
结论:
- 特定的口腔属,Veillonella,Prevotella和Capnocytophaga,与PTB相关.
- 这种关联独立于临床感染和其他妊娠并发症.
- 需要进一步的研究来阐明这些种类在PTB病因学中的作用.
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