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相关概念视频

Cerebellum: Anatomical Regions01:17

Cerebellum: Anatomical Regions

1.8K
The cerebellum, also known as the "little brain," is located in the posterior cranial fossa, inferior to the tentorium cerebelli and dorsal to the brainstem. It plays a significant role in motor control, coordination, and proprioception.
Cerebellar Structure
Externally, the cerebellum features a highly convoluted surface with numerous folia (narrow ridges) separated by shallow sulci (grooves). The cerebellum is divided into two hemispheres by a thin median structure known as the vermis. The...
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Major Somatic Sensory Pathways01:28

Major Somatic Sensory Pathways

1.0K
Sensory impulses related to touch, pressure, vibration, and proprioception from various body parts, such as the limbs, trunk, neck, and posterior head, travel to the cerebral cortex through the posterior column-medial lemniscus pathway. The pathway’s name derives from the two white-matter tracts that convey the impulses: the spinal cord's posterior column and the brainstem's medial lemniscus. First-order sensory neurons extend their axons into the spinal cord, forming the...
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REM Sleep Behavior Disorder01:15

REM Sleep Behavior Disorder

251
REM Sleep Behavior Disorder (RBD) is a sleep disorder characterized by the absence of muscle paralysis that normally occurs during the REM phase of sleep. This absence allows individuals to physically act out their dreams, which are often vivid and disturbing. Common behaviors exhibited during episodes include kicking, punching, and yelling. These actions can be dangerous, potentially leading to injuries for the person with RBD or their bed partner.
RBD is significantly associated with...
251
Neural Regulation01:37

Neural Regulation

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Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
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相关实验视频

Updated: Jul 18, 2025

Author Spotlight: Deciphering the Role of ATM in Ataxia-Telangiectasia and the Associated Cerebellar Degeneration
08:41

Author Spotlight: Deciphering the Role of ATM in Ataxia-Telangiectasia and the Associated Cerebellar Degeneration

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关于BDNF和大脑缩症的研究

Robert Lalonde1, Magali Hernandez1,2, Catherine Strazielle1,2

  • 1Université de Lorraine, Laboratoire Stress, Immunité, Pathogènes EA 7300, Campus Santé, 9 avenue de la Forêt de Haye, 54500 Vandoeuvre-les-Nancy, France.

Current drug research reviews
|August 23, 2023
PubMed
概括

大脑衍生神经营养因子 (BDNF) 通过取代减少的BDNF水平来治疗小脑神经退行症具有前途. 这项研究探讨了它在各种小脑疾病中的有效性,包括那些正常的BDNF水平或联合大脑区域损伤的人.

科学领域:

  • 神经科学是一个神经科学.
  • 分子生物学分子生物学
  • 遗传学 是一个遗传学.

背景情况:

  • 影响小脑的神经退行性疾病通常表现为脑衍生神经营养因子 (BDNF) 或其受体TrkB的水平降低.
  • 替代BDNF治疗是一种潜在的策略,可以抵消小脑退化.

研究的目的:

  • 为了评估BDNF在小脑病理中的治疗效果.
  • 调查BDNF在正常BDNF水平的条件下以及涉及小脑和基底腺结合损伤的病例中的BDNF疗效.

主要方法:

  • 从各种小脑变性小鼠和老鼠模型的实验证据的审查,包括转基因和基因淘汰模型.
  • 分析涉及lentivector介导基因传递和BDNF过度表达的转基因线的研究.

主要成果:

  • 在多个临床前模型中,BDNF信号传递已在抵消小脑退化和感觉运动缺陷方面表现出有效.
  • 有证据表明,BDNF可能在降低BDNF水平的条件下有益.

结论:

  • 对于小脑神经退行症,BDNF显示出治疗潜力,特别是当BDNF水平降低时.
  • 需要进一步的研究,以确定BDNF在大脑小脑病理中的有效性,BDNF水平正常,以及影响多个大脑区域的复杂病例.
关键词:
弗里德里希的过敏症是什么神经营养素的神经营养素谷类小麦的发展.小粒细胞突变体旋转杆. 旋转杆. 这是一个旋转杆.脊髓大脑小骨性动脉衰竭

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