渐进性纤维化间歇性肺部疾病.
Carlos A C Pereira1, Soraya Cordero2, Ana Carolina Resende2
1. Programa de Assistência e Pesquisa em Doenças Pulmonares Intersticiais, Departamento de Clínica Médica, Serviço de Pneumologia, Universidade Federal de São Paulo, São Paulo (SP) Brasil.
概括
渐进性纤维化间歇性肺病 (PF-ILDs) 影响30%的ILD患者. 像宁泰达尼布这样的抗纤维素药物显示出减缓疾病进展的潜力,为患者提供了新的希望.
科学领域:
- 肺部病理学 肺部病理学
- 纤维化间歇性肺病 纤维化间歇性肺病
- 药理学 药理学是指药理学的学科.
背景情况:
- 间歇性肺部疾病 (ILD) 往往具有导致渐进性纤维化 (PF-ILD) 的共同机制.
- PF-ILD影响约30%的ILD患者,包括慢性过敏性肺炎和异常性肺纤维化等疾病.
- 准确的诊断至关重要,因为尽管接受治疗,PF-ILD仍在进展.
研究的目的:
- 审查目前对渐进性纤维化间歇性肺部疾病 (PF-ILDs) 的理解.
- 评估抗纤维素药物在治疗PF-ILD中的有效性.
- 突出进一步研究风险标志物和治疗反应的需要.
主要方法:
- 关于PF-ILD机制,诊断和治疗的现有文献的审查.
- 对PF-ILD患者的抗纤维素药物 (nintedanib,pirfenidone) 临床试验数据的分析.
- 审查巴西和美国对宁泰达尼布的监管批准.
主要成果:
- 在PF-ILD患者中,丁丁达尼布在与安慰剂相比,显著减缓了肺功能下降 (平均差异为107.0毫升/年).
- 皮尔芬尼在未分类的ILD和其他ILD患者中表现出类似的积极结果.
- 美国和巴西的监管机构已经批准了宁泰达尼布用于PF-ILD治疗.
结论:
- 抗纤维素疗法,特别是宁泰达尼布,在管理渐进性纤维化间歇性肺部疾病方面取得了重大进展.
- 早期识别风险因素和个性化治疗策略对于改善患者结果至关重要.
- 持续的研究对于确定疾病进展和治疗反应的预测标志物至关重要.
相关概念视频
01:20Chronic Obstructive Pulmonary Disease-I: Introduction
2.8K
Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.
2.8K
01:20Chronic Obstructive Pulmonary Disease-II: Pathophysiology
2.8K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Chronic Inflammation
2.8K
01:30Pulmonary Hypertension: Classification and Pathogenesis
222
Pulmonary hypertension (PH) is a severe health condition in which the mean pulmonary arterial pressure increases to 25 mmHg or more, even when the body is at rest. This high pressure in the blood vessels that transport blood from the heart to the lungs can cause various symptoms, including shortness of breath, can lead to right heart failure, and significantly affect the overall quality of life.
There are various classifications for PH, each relating to different underlying causes and also...
There are various classifications for PH, each relating to different underlying causes and also...
222
01:24Chronic Pancreatitis I: Introduction
112
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
112
01:20COPD: Pathogenesis and Clinical Features
341
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
341
01:25Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.
2.8K
Understanding the variety of primary symptoms and systemic complications that characterize chronic obstructive pulmonary disease (COPD) is crucial for healthcare professionals.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
2.8K