对于外部固定装置的高度粘合性的抗菌涂层
Mikhail Bredikhin1, Sushant Sawant1, Christopher Gross2
1Department of Bioengineering, Clemson University, Clemson, SC 29634, USA.
Gels (Basel, Switzerland)
|August 25, 2023
概括
骨科针的新型凝涂层具有强大的粘附性和抗微生物特性,显著降低了针部位感染的风险,并改善了骨折固定结果.
科学领域:
- 整形外科手术 整形外科手术
- 生物材料科学 生物材料科学
- 预防传染病 预防传染病
背景情况:
- 穿皮钉技术破坏皮肤屏障,导致针部位感染,在外部固定后的发病率高达100%.
- 针部位感染可能会导致松,增加疼痛和更严重的并发症,如骨髓炎,需要有效的预防策略.
- 目前用于骨科植入物的抗微生物涂层经常患有粘附性差,在植入过程中在剪切力下脱离.
研究的目的:
- 开发用于骨科针的高度粘合性,可释放药物的涂层,以防止针部感染.
- 创建新的凝涂层,在剪切应力下植入后保持抗微生物有效性.
- 为了减少在骨科手术中与植入物相关的感染相关的发病率和成本.
主要方法:
- 开发了两种凝涂层类型:基于合成聚甘油甲基酸盐的合成涂层和基于天然奇托的涂层.
- 在强大的剪切力下测试涂层粘附于钉子,模拟植入条件.
- 将抗生素纳入凝涂层并评估骨植入K线的抗菌疗效.
主要成果:
- 合成和天然凝涂层都表现出对钉子的强粘附性,能够承受显著的剪切力而不损坏.
- 带有抗生素的K-线与开发的涂层保留了植入和从骨头移除后的抗菌有效性.
- 这些涂层被证明是坚固的,这表明了在骨科植入物中改善抗微生物药物传递的潜力.
结论:
- 新型合成和基托基的凝涂层为增强骨科针的抗微生物有效性和耐用性提供了有前途的解决方案.
- 这些高度粘合性的涂层可以有效地传递抗生素并抵抗脱落,解决当前技术的一个关键局限性.
- 开发的涂层技术有可能显著降低骨科手术中针位感染的发生率和影响.
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