人类侵略的遗传学和表观遗传学.
Veronika V Odintsova1, Fiona A Hagenbeek2, Camiel M van der Laan3
1Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands; Amsterdam Reproduction and Development (AR&D) Research Institute, Amsterdam, The Netherlands; Mental Health Division, Amsterdam Public Health (APH) Research Institute, Amsterdam, The Netherlands.
Handbook of clinical neurology
|August 26, 2023
概括
遗传研究表明,侵略性是50%的遗传性. 全基因组关联研究 (GWAS) 和全表观基因组关联研究 (EWAS) 正在确定遗传和表观遗传联系,但目前仅解释了侵略变异的一小部分.
科学领域:
- 行为遗传学行为遗传学
- 分子精神病学分子精神病学
- 基因组学和奥米克学
背景情况:
- 人类的侵略性表现出显著的个体差异,但其生物和分子遗传基础在很大程度上是未知的.
- 以前的研究表明,侵略性具有相当大的遗传性,从家庭和双胞胎研究中估计约为50%.
- 使用一种广泛的现象型定义,包括侵略性,反社会行为,行为障碍和反对性挑性障碍.
结论:
- 未来增加GWAS和EWAS的样本大小,预计将产生更多的发现.
- 综合基因组,表观基因组和代谢基因组数据的多学科方法对于全面的理解至关重要.
- 需要进一步的研究才能充分阐明人类侵略的复杂分子基础.
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