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相关实验视频

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Design and Fabrication of Ultralight Weight, Adjustable Multi-electrode Probes for Electrophysiological Recordings in Mice
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用于神经科学应用的3D打印可定制的微型采样设备.

Patrick M Pysz1,2, Julia K Hoskins3,4, Min Zou2,3,4

  • 1Department of Chemistry and Biochemistry, University of Arkansas, Fayetteville, Arkansas 72701, United States.

ACS chemical neuroscience
|August 30, 2023
PubMed
概括

先进的3D打印,特别是双光子聚合,正在使神经科学研究能够创建复杂的体内大脑设备. 这些创新的微采样设备为脑组织操纵和测量提供了增强的能力.

关键词:
通过3D打印打印3D打印.添加剂制造 添加剂制造 添加剂制造微透析是一种微透析.微型制造是指微型制造.微流体学 在微流体学方面微量采样微量采样

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科学领域:

  • 神经科学是一个神经科学.
  • 生物医学工程 生物医学工程
  • 材料科学 材料科学 材料科学

背景情况:

  • 神经科学家需要多功能 in vivo 大脑设备进行化学/物理测量和组织操纵 (药物输送,电刺激,光遗传学).
  • 当前设备的局限性阻碍了先进的神经科学研究和体内测量.

研究的目的:

  • 为了证明3D打印在创造下一代体内大脑设备方面的潜力.
  • 突出使用3D打印用于微型采样设备的优点和挑战.

主要方法:

  • 探索3D打印技术,重点是用于纳米尺度特征制造的双光子聚合.
  • 分析3D打印在创建核心设备和外围组件中的应用.

主要成果:

  • 3D打印为先进的神经科学测量设备提供了前所未有的灵活性和快速处理.
  • 两光子聚合被确定为制造具有nm到μm特征大小的微采样设备的关键技术.
  • 3D打印促进了微采样器件设计和组装的新改进.

结论:

  • 3D打印即将彻底改变神经科学家在体内脑部设备的开发.
  • 通过3D打印制造的微采样设备代表了迈向下一代神经科学工具的重要一步.