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相关概念视频

Hair Cells01:22

Hair Cells

40.7K
Hair cells are the sensory receptors of the auditory system—they transduce mechanical sound waves into electrical energy that the nervous system can understand. Hair cells are located in the organ of Corti within the cochlea of the inner ear, between the basilar and tectorial membranes. The actual sensory receptors are called inner hair cells. The outer hair cells serve other functions, such as sound amplification in the cochlea, and are not discussed in detail here.
40.7K
The Cochlea01:13

The Cochlea

45.2K
The cochlea is a coiled structure in the inner ear that contains hair cells—the sensory receptors of the auditory system. Sound waves are transmitted to the cochlea by small bones attached to the eardrum called the ossicles, which vibrate the oval window that leads to the inner ear. This causes fluid in the chambers of the cochlea to move, vibrating the basilar membrane.
45.2K
Auditory Pathway01:15

Auditory Pathway

5.5K
Auditory pathways constitute the complex neural circuits responsible for transmitting and interpreting auditory information from the peripheral auditory system to the brain. Sound waves are initially captured by the outer ear, funneled through the ear canal, and reach the tympanic membrane (eardrum). These vibrations are transmitted via the middle ear's ossicles to the inner ear's cochlea.
When viewed cross-sectionally, the cochlea reveals the scala vestibuli and scala tympani flanking...
5.5K
Anatomy of the Ear01:16

Anatomy of the Ear

8.4K
Auditory sensation, commonly called hearing, involves the transformation of sonic waves into neural impulses facilitated by the structures of the auditory organ. The prominent, flesh-like structure on the side of the head, called the auricle, directs sound waves towards the auditory canal. The auricle is often mislabeled as the pinna, a term more aligned with mobile structures like a feline's external ear. The auditory canal penetrates the cranium via the external auditory meatus of the...
8.4K
Equilibrium and Balance01:15

Equilibrium and Balance

4.8K
The inner ear assumes dual functionalities of auditory perception and equilibrium maintenance. The vestibule is the organ responsible for balance. This organ contains mechanoreceptors, specifically hair cells, endowed with stereocilia, which aid in deciphering information regarding the position and motion of our heads. Two intrinsic components, the utricle and saccule, help perceive head position, while the semicircular canals track head movement. Neurological messages initiated in the...
4.8K
The Auditory Ossicles01:11

The Auditory Ossicles

1.7K
The auditory ossicles of the middle ear transmit sounds from the air as vibrations to the fluid-filled cochlea. The auditory ossicles consist of two malleus (hammer) bones, two incus (anvil) bones, and two stapes (stirrups), one on each side. These bones develop during the fetal stage and are the ones to ossify first. They are fully mature at birth and do not grow afterward.
The aptly named stapes look very much like a stirrup. The three ossicles are unique to mammals, and each plays a role in...
1.7K

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相关实验视频

Updated: Jul 16, 2025

Dextran Labeling and Uptake in Live and Functional Murine Cochlear Hair Cells
05:55

Dextran Labeling and Uptake in Live and Functional Murine Cochlear Hair Cells

Published on: February 8, 2020

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mTORC2调节了听觉毛细胞结构和功能.

Maurizio Cortada1, Soledad Levano1, Michael N Hall2

  • 1Department of Biomedicine, University of Basel, CH-4031 Basel, Switzerland.

iScience
|September 11, 2023
PubMed
概括
此摘要是机器生成的。

拉巴胺素复合体2 (mTORC2) 途径的机械性标对听觉感觉毛细胞 (HC) 的结构和功能至关重要. 在HC中mTORC2的干扰会导致逐渐的听力损失和头发细胞退化.

关键词:
细胞生物学 细胞生物学分子生物学分子生物学

更多相关视频

Auditory Brainstem Response and Outer Hair Cell Whole-cell Patch Clamp Recording in Postnatal Rats
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Auditory Brainstem Response and Outer Hair Cell Whole-cell Patch Clamp Recording in Postnatal Rats

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Author Spotlight: Advancements in Cultivating Mouse Hair Cells for Auditory Research
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Author Spotlight: Advancements in Cultivating Mouse Hair Cells for Auditory Research

Published on: September 15, 2023

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相关实验视频

Last Updated: Jul 16, 2025

Dextran Labeling and Uptake in Live and Functional Murine Cochlear Hair Cells
05:55

Dextran Labeling and Uptake in Live and Functional Murine Cochlear Hair Cells

Published on: February 8, 2020

7.4K
Auditory Brainstem Response and Outer Hair Cell Whole-cell Patch Clamp Recording in Postnatal Rats
09:23

Auditory Brainstem Response and Outer Hair Cell Whole-cell Patch Clamp Recording in Postnatal Rats

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Author Spotlight: Advancements in Cultivating Mouse Hair Cells for Auditory Research
06:07

Author Spotlight: Advancements in Cultivating Mouse Hair Cells for Auditory Research

Published on: September 15, 2023

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科学领域:

  • 细胞生物学 细胞生物学
  • 神经科学是一个神经科学.
  • 耳鼻喉科 耳鼻喉科 耳鼻喉科

背景情况:

  • 拉巴胺素 (mTOR) 途径的机械性标调节细胞生长.
  • 在内耳,特别是感官毛细胞 (HCs) 中mTOR复合体2 (mTORC2) 的特定作用仍然在很大程度上未被描述.

研究的目的:

  • 为了研究mTORC2在听觉感官毛细胞中的功能.
  • 阐明mTORC2在维持HC结构和功能中的作用背后的分子机制.

主要方法:

  • 发毛细胞特异性Rictor淘汰 (HC-RicKO) 鼠标的生成.
  • 使用扭曲产品的音响排放 (DPOAEs) 进行审计功能评估.
  • 耳毛细胞和突触结构的超结构分析.

主要成果:

  • HC-RicKO小鼠表现出早期发病,渐进和严重的听力损失.
  • 外皮毛细胞 (OHC) 功能障碍被增加的DPOAE值所表明.
  • 超结构性缺陷包括OHCs中缩的立体,内毛细胞 (IHC) 突触的减少,动素细胞骨的破坏,以及IHCs中的Ca2+道的混乱.

结论:

  • mTORC2信号通路对于调节听觉毛细胞的结构和功能至关重要.
  • mTORC2通过调节actin细胞骨架来调节耳HCs.
  • 这些发现为耳毛细胞和听力的一个关键调节器提供了分子洞察力.