双阴性神经脊髓炎光学谱系障碍
Yan Wu1, Ruth Geraldes2, Maciej Juryńczyk3
1Neurology Department of First Affiliated Hospital of Kunming Medical University, Kunming, China/Nuffield Department of Clinical Neurosciences, Oxford University Hospitals, Oxford, UK.
概括
双阴性神经炎光学谱障碍 (DN NMOSD) 是一个诊断挑战,因为这种综合征有异质的原因和临床表现,与抗体阳性NMOSD不同.
科学领域:
- 神经免疫学 神经免疫学
- 神经学 神经学
背景情况:
- 神经omyelitis光学谱系障碍 (NMOSD) 通常与抗水素-4 (AQP4-IgG) 或髓寡细胞糖蛋白 (MOG-IgG) 的抗体有关.
- 一组被称为双阴性 (DN) NMOSD的患者缺乏这些特定抗体,这给诊断和治疗带来了挑战.
- DN NMOSD代表了一种异质综合征,而不是一种单一的疾病,具有可变的临床过程和与其他神经疾病的潜在重叠.
研究的目的:
- 根据不断发展的诊断试验,重新评估抗体阴性NMOSD的定义.
- 确定DN NMOSD的临床特征和病理生理学,并将其与抗体阳性NMOSD进行比较.
- 总结实验室和MRI发现,并讨论DN NMOSD目前的治疗策略.
主要方法:
- 对现有文献进行专题综述.
- 分析临床,实验室和成像数据.
- 对DN NMOSD与抗体阳性NMOSD和其他模拟物的比较.
主要成果:
- 随着AQP4-IgG和MOG-IgG测试的进步,DN NMOSD的定义也在不断发展.
- DN NMOSD表现出不同的临床表现,从单相到慢性形式.
- 导致DN NMOSD的病理生理机制可能是异质的.
结论:
- 由于其异质性,DN NMOSD需要仔细的诊断考虑.
- 需要进一步的研究来阐明DN NMOSD的具体机制和优化治疗方法.
- 区分DN NMOSD与抗体阳性NMOSD和模仿物对于适当的管理至关重要.
相关概念视频
Myasthenia Gravis: Diagnostic Tests
960
Myasthenia gravis is an autoimmune condition affecting neuromuscular transmission, causing generalized weakness in skeletal muscles. Initial diagnoses rely on patients' signs, symptoms, and medical history. The challenge lies in distinguishing myasthenia from other muscular dystrophies. An important diagnostic feature is the significant improvement of symptoms after administering anticholinesterase inhibitors.
The edrophonium test is a diagnostic tool for myasthenia gravis. It involves...
The edrophonium test is a diagnostic tool for myasthenia gravis. It involves...
960
Negative and Cognitive Symptoms of Schizophrenia
60
Negative symptoms of schizophrenia indicate a reduction or absence of typical behaviors and emotional responses found in healthy individuals, while positive symptoms reflect an excess or distortion of normal functioning.
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
60
Myasthenia Gravis: Overview and Treatment
1.6K
Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
1.6K
Neuromuscular Junction And Blockade
3.1K
The site of chemical communication between a motor neuron and a muscle fiber is called the neuromuscular junction (NMJ). The end of the motor neuron at the NMJ divides into a cluster of synaptic end bulbs. The cytoplasm of these bulbs consists of synaptic vesicles enclosing acetylcholine molecules, the principal neurotransmitter released at the NMJ. The region opposite the synaptic bulb that ends in the muscle fiber is called the motor end plate, which has acetylcholine receptors. Within the...
3.1K
Insensitive Nuclei Enhanced by Polarization Transfer (INEPT)
368
Insensitive Nuclei Enhanced by Polarization Transfer (INEPT) is an advanced Nuclear Magnetic Resonance (NMR) technique specifically designed to detect and enhance the signals of low-abundance nuclei, such as carbon-13 and nitrogen-15, in small molecules. The fundamental principle behind INEPT is the transfer of polarization from a more abundant and highly polarizable nucleus, typically hydrogen-1, to the low-abundance nucleus of interest. This process effectively boosts the NMR signal of the...
368


