Jove
Visualize
联系我们

相关概念视频

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Managing dangerous liaisons: lessons from <i>Helicobacter pylori</i> for understanding bacterial carcinogenesis.

Journal of bacteriology·2026
Same author

Metabolic cross-feeding of a dietary antioxidant enhances anaerobic energy metabolism by human gut bacteria.

Cell host & microbe·2025
Same author

An affinity-based depletion strategy for evaluating the effects of ergothioneine on bacterial physiology.

Cell chemical biology·2025
Same author

Microbial metabolism of host-derived antioxidants.

Current opinion in chemical biology·2024
Same author

Thoughts for the future.

Nature chemical biology·2024
Same author

Isotope tracing reveals bacterial catabolism of host-derived glutathione during Helicobacter pylori infection.

PLoS pathogens·2023
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关实验视频

Updated: Jul 15, 2025

Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses
08:38

Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses

Published on: February 22, 2019

5.9K

基于活动的工具,用于在感染期间查询宿主生物学.

Renuka Ramanathan1,2, Stavroula K Hatzios1,2,3

  • 1Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06520 USA.

Israel journal of chemistry
|September 25, 2023
PubMed
概括

基于活动的蛋白质分析 (ABPP) 揭示了宿主转化后修饰 (PTMs),这些修饰在感染期间调节细胞信号传递. 这种方法可以识别针对病原体的新疗法的宿主目标.

关键词:
酶 是一种酶.主体微生物的相互作用.感染的感染感染.蛋白质的修改 蛋白质的修改蛋白质组学 蛋白质组学

更多相关视频

Arbovirus Infections As Screening Tools for the Identification of Viral Immunomodulators and Host Antiviral Factors
06:02

Arbovirus Infections As Screening Tools for the Identification of Viral Immunomodulators and Host Antiviral Factors

Published on: September 13, 2018

6.9K
High-Throughput Transcriptome Analysis for Investigating Host-Pathogen Interactions
14:58

High-Throughput Transcriptome Analysis for Investigating Host-Pathogen Interactions

Published on: March 5, 2022

4.3K

相关实验视频

Last Updated: Jul 15, 2025

Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses
08:38

Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses

Published on: February 22, 2019

5.9K
Arbovirus Infections As Screening Tools for the Identification of Viral Immunomodulators and Host Antiviral Factors
06:02

Arbovirus Infections As Screening Tools for the Identification of Viral Immunomodulators and Host Antiviral Factors

Published on: September 13, 2018

6.9K
High-Throughput Transcriptome Analysis for Investigating Host-Pathogen Interactions
14:58

High-Throughput Transcriptome Analysis for Investigating Host-Pathogen Interactions

Published on: March 5, 2022

4.3K

科学领域:

  • 细胞微生物学 细胞微生物学
  • 生物化学 生物化学
  • 免疫学 免疫学 免疫学

背景情况:

  • 宿主细胞通过动态细胞信号调节来检测并对病原体作出反应.
  • 翻译后修改 (PTMs) 迅速改变蛋白质的功能和相互作用,调节信号通路.
  • 基于活动的蛋白质分析 (ABPP) 使用化学探针来识别影响宿主-病原体相互作用的PTM.

研究的目的:

  • 审查ABPP在发现宿主PTM的近期应用.
  • 要突出在感染期间参与宿主信号调制的酶.
  • 强调ABPP在理解宿主反应和确定治疗点方面的作用.

主要方法:

  • 使用化学探针进行酶功能的广泛分析.
  • 评估侧链反应性以检测蛋白质活性变化.
  • 应用ABPP研究感染细胞中的宿主PTM.

主要成果:

  • ABPP在发现微生物致病机制方面发挥了重要作用.
  • 最近的研究重点关注ABPP对宿主衍生PTM的应用.
  • 这种技术揭示了在感染期间对宿主信号传递至关重要的酶和PTM.

结论:

  • ABPP是一个强大的工具,用于调查宿主对感染的反应.
  • 该技术有助于识别宿主导的治疗点.
  • 了解宿主PTM对于开发新的抗感染策略至关重要.