Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Peptidoglycan Synthesis01:28

Peptidoglycan Synthesis

43
Structure of PeptidoglycanPeptidoglycan is a vital structural component of the bacterial cell wall, providing mechanical strength and shape to the cell. It consists of repeating units of two sugars—N-acetylglucosamine (NAG) and N-acetylmuramic acid (NAM)—linked by β-1,4 glycosidic bonds. These sugar chains are cross-linked by short peptide chains, forming a mesh-like polymer that surrounds the bacterial plasma membrane.Cytoplasmic Phase – Precursor SynthesisPeptidoglycan...
43
ATP and Macromolecule Synthesis01:28

ATP and Macromolecule Synthesis

5.6K
Biological macromolecules are organic compounds, predominantly composed of carbon atoms. The carbon atoms are covalently bonded with hydrogen, oxygen, nitrogen, and other minor elements. There are four major biological macromolecule classes: carbohydrates, lipids, proteins, and nucleic acids.
Most macromolecules are composed of single subunits, or building blocks, called monomers. The monomers combine with each other using covalent bonds to form larger molecules known as polymers.
Conversion of...
5.6K
Biosynthesis of Nucleic Acids01:28

Biosynthesis of Nucleic Acids

67
Nucleic acid biosynthesis is a fundamental biochemical process that produces the purine and pyrimidine nucleotides essential for DNA and RNA synthesis. This pathway maintains a balanced nucleotide pool, preventing imbalances that could jeopardize genetic integrity and cellular function. Given the crucial role of nucleotides, their synthesis is tightly regulated to ensure proper cellular homeostasis.Purine BiosynthesisThe biosynthesis of purine nucleotides begins with ribose-5-phosphate, a...
67
Nucleic Acid Structure01:25

Nucleic Acid Structure

6.2K
The pentose sugar in DNA is deoxyribose, while in RNA the pentose sugar is ribose. The difference between the sugars is the presence of the hydroxyl group on the ribose's second carbon and a hydrogen on the deoxyribose's second carbon. The phosphate residue attaches to the hydroxyl group of the 5′ carbon of one sugar and the hydroxyl group of the 3′ carbon of the sugar of the next nucleotide, which forms  a 5′ to 3′ phosphodiester linkage.
DNA Structure
DNA...
6.2K
Nucleic Acids02:43

Nucleic Acids

44.3K
Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes,...
44.3K
Nucleic acids02:43

Nucleic acids

163.5K
Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes,...
163.5K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Multivessel Spontaneous Coronary Artery Dissection in the Setting of Anomalous Left Coronary Arteries.

European journal of case reports in internal medicine·2023
Same author

New insights into the electrochemical performance of precursor derived Si(Nb)OC composites as anode materials for batteries.

RSC advances·2023
Same author

Role of oxidative stress in diabetes-induced complications and their management with antioxidants.

Archives of physiology and biochemistry·2023
Same author

Systemic Haemophilus parainfluenzae Infection Manifesting With Endocarditis and Membranoproliferative Glomerulonephritis.

Cureus·2023
Same author

Oral Probenecid for Nonhospitalized Adults with Symptomatic Mild-to-Moderate COVID-19.

Viruses·2023
Same author

The effect of cooling garments to improve physical function in people with multiple sclerosis: A systematic review and meta-analysis.

Multiple sclerosis and related disorders·2023
Same journal

Tumor-targeted activatable molecular agent for synergistic chemo-photodynamic therapy.

Bioorganic chemistry·2026
Same journal

Computational design and experimental validation of peptide inhibitors targeting the p53-COP1 interaction to suppress p53 ubiquitination.

Bioorganic chemistry·2026
Same journal

Benzalkonium chloride disrupts human placental progesterone synthesis via locking NAD<sup>+</sup> pocket in 3β-Hydroxysteroid dehydrogenase 1 and rat homolog: docking evidence and 3D-QSAR, and experiment risk assessment.

Bioorganic chemistry·2026
Same journal

Terephthaloyl-based amide-linked derivatives and polymeric networks with selective cytotoxicity: In vitro evaluation, Molecular docking, Molecular dynamics, and DFT insights.

Bioorganic chemistry·2026
Same journal

Synthesis and biological evaluation of C6-modified Celastrol derivatives as anti-inflammatory agents targeting the NF-κB signaling pathway.

Bioorganic chemistry·2026
Same journal

Synthesis and biological evaluation of 6,9-disubstituted purine analogues inducing autophagy-mediated apoptosis and potentiating carboplatin response in high-grade serous ovarian cancer.

Bioorganic chemistry·2026
查看所有相关文章

相关实验视频

Updated: Jul 15, 2025

Self-Assembly of Gamma-Modified Peptide Nucleic Acids into Complex Nanostructures in Organic Solvent Mixtures
08:15

Self-Assembly of Gamma-Modified Peptide Nucleic Acids into Complex Nanostructures in Organic Solvent Mixtures

Published on: June 26, 2020

4.3K

核酸:合成和脊柱修改的最新进展

Gurpreet Singh1, Vikramdeep Monga2

  • 1Department of Pharmaceutical Chemistry, ISF College of Pharmacy, GT Road, Ghal Kalan, Moga 142001, Punjab, India.

Bioorganic chemistry
|September 25, 2023
PubMed
概括
此摘要是机器生成的。

核酸 (PNA) 是DNA和RNA的合成模仿物,对目标具有很高的亲和力. 本综述探讨了骨干修改,以提高PNA稳定性和选择性,用于治疗应用.

关键词:
背骨修改是指背骨的修改.它们是DNA DNA DNA DNA.诊断 诊断 诊断 诊断 诊断在PNA/DNA双重复制中.这就是PNAs.类核酸是核酸中的一种.类合成 类合成探测器 探测器

更多相关视频

Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids
09:04

Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids

Published on: September 21, 2017

9.6K
Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation
08:48

Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation

Published on: January 26, 2016

11.9K

相关实验视频

Last Updated: Jul 15, 2025

Self-Assembly of Gamma-Modified Peptide Nucleic Acids into Complex Nanostructures in Organic Solvent Mixtures
08:15

Self-Assembly of Gamma-Modified Peptide Nucleic Acids into Complex Nanostructures in Organic Solvent Mixtures

Published on: June 26, 2020

4.3K
Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids
09:04

Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids

Published on: September 21, 2017

9.6K
Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation
08:48

Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation

Published on: January 26, 2016

11.9K

科学领域:

  • 生物化学 生物化学
  • 药用化学 医学化学
  • 分子生物学分子生物学

背景情况:

  • 核酸是挑战蛋白质标的理想药物候选者.
  • 核酸 (PNA) 是合成核酸模仿物,具有骨架.
  • 在生物技术,诊断和治疗方面,PNAs具有潜力.

研究的目的:

  • 审查修改PNA骨干的战略.
  • 为了提高PNAs的标选择性和体内稳定性.
  • 总结PNAs的生物活动.

主要方法:

  • 关于PNA合成和修改的文献综述.
  • 对骨干改变策略的分析.
  • 关于PNA生物活动的研究汇编.

主要成果:

  • PNA骨干修改提高了目标选择性和稳定性.
  • 由于其未充电的,灵活的聚胺骨干,PNAs具有很高的亲和力和特异性.
  • 已经研究了PNAs的各种生物活动.

结论:

  • 脊柱修改是优化PNA治疗潜力的关键.
  • PNAs代表了一类有希望的合成分子用于药物开发.
  • 对PNA生物活动的进一步研究是有必要的.