菌C171:调节对急性致命病毒挑战的免疫反应
Jielan Mi1, Tana He1, Xinyun Hu1
1State Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China.
International journal of antimicrobial agents
|September 27, 2023
概括
菌 (Enterococcus faecium C171) 显示出强烈的抗炎和抗感染作用,将的死亡率降低了75%. 它的细胞外囊泡也调解免疫激活,这表明它有可能治疗炎症性疾病和病毒感染.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
背景情况:
- 连体细菌在调节宿主对感染的免疫反应方面发挥着至关重要的作用.
- 新分离的菌株Enterococcus faecium C171表现出与已知的益生菌相似的特征,包括显著的抗炎和抗感染特性.
研究的目的:
- 研究Enterococcus faecium C171及其细胞外囊泡的免疫调节和抗感染作用.
- 在急性传染病的模型中评估E. faecium C171的治疗潜力.
主要方法:
- 在体外试验测试以评估诸如pro-Caspase-1和interleukin-1β (IL-1β) 等促炎媒介的抑制.
- 特朗斯韦尔系统的实验证实了炎症抑制.
- 在特定无病原体 (SPF) 的中,口服E. faecium C171感染了一种病毒性传染病.
- 对肠道微生物群组成,免疫细胞群 (CD3+,CD4+,CD8+),T细胞增殖和干扰素-γ分泌的分析.
主要成果:
- 在体外,E. faecium C171抑制了pro-Caspase-1和IL-1β的产生.
- 细菌细胞外囊泡 (Efm-C171-BEVs) 被确定为抗感染和免疫激活作用的关键媒介.
- 在SPF中,口服E. faecium C171增加了有益的肠道细菌 (Enterococcus,Lactobacillus).
- E. faecium C171在感染传染病的中显著降低了75%的死亡率.
- 治疗增强了免疫调节和杀伤性T细胞,增强了T细胞的增殖,增加了干扰素-γ的分泌.
结论:
- 菌C171表现出强大的抗炎和抗感染能力,部分通过其细胞外囊泡进行介导.
- 在宿主模型中,E. faecium C171有效调节肠道微生物群,增强细胞和幽默免疫力.
- 无论是E. faecium C171还是其细胞外囊泡 (Efm-C171-BEVs),都显示出对急性炎症和病毒感染的辅助疗法具有前景.
关键词:
这是一种急性炎症.抗感染作用 抗感染作用抗炎药物 抗炎药物 抗炎药物细菌的细胞外囊泡.肠球菌 (Enterococcus faecium) 是一个有毒的菌株.在IBDV中,IBDV是IBDV.这是一种免疫调节剂.传染性乡村病病毒感染.益生菌 益生菌 益生菌更多相关视频
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