对形状和尺寸索引的统计推断用于计数过程
Yifei Sun1, Sy Han Chiou2, Kieren A Marr3
1Department of Biostatistics, Columbia University Mailman School of Public Health, 722 W168th St., New York, New York 10032, U.S.A.
Biometrika
|October 4, 2023
概括
本研究引入了一种灵活的半参数模型,用于使用单指数模型进行反复事件分析. 新的框架提高了可解释性,并为时间到事件数据提供了可靠的估计方法.
科学领域:
- 生物统计学 生物统计学
- 生存分析的分析.
- 统计建模 统计建模
背景情况:
- 单指数模型在时间到事件分析中越来越受欢迎,因为它们的灵活性和尺寸缩小能力.
- 循环事件数据分析在随时间推移的事件率建模方面提出了独特的挑战.
- 现有的模型可能缺乏可解释性或与复杂的共同变量效应作斗争.
研究的目的:
- 为循环事件计数过程的速率函数提出一个新的半参数框架.
- 使用单指数模型建模速率函数的大小和形状元件.
- 确保协变效应的方向解释性,并包括现有模型.
主要方法:
- 使用单一指数模型来计算速率函数的尺寸和形状组件.
- 对链接函数施加单调约束,以提高可解释性.
- 为回归参数开发一个基于等级的两步估计程序,适应信息审查.
- 引入对形状和尺寸独立性的假设测试,以指导模型选择.
主要成果:
- 拟议的半参数模型为反复事件数据提供了增强的解释性.
- 两个步骤的估计程序产生了具有根-n收率的非对称正常估计器.
- 该方法通过模拟研究和在血液造血干细胞移植中的现实应用得到了验证.
结论:
- 拟议的框架为建模反复事件数据提供了一种灵活和可解释的方法.
- 开发的估计和测试程序在统计学上是合理的,并且可以在实践中应用.
- 这种方法提升了时间到事件分析,特别是复杂的反复事件过程.
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