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Updated: Jul 13, 2025

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人体IgG亚类和全型对补充激活的影响

Timon Damelang1,2,3, Steven W de Taeye1,2, Rosa Rentenaar1

  • 1Department of Immunopathology, Sanquin Research and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.

Journal of immunology (Baltimore, Md. : 1950)
|October 16, 2023
PubMed
概括

免疫球蛋白G (IgG) 类型的结构变异显著影响补充激活和补充依赖细胞毒性 (CDC). 特定的IgG2变体和IgG1和IgG3亚类之间的差异影响细胞解质,为治疗抗体设计提供了洞察力.

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