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相关概念视频

Imaging Studies III: Gastrointestinal Motility Studies and Virtual Colonoscopy01:26

Imaging Studies III: Gastrointestinal Motility Studies and Virtual Colonoscopy

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This lesson explores three gastrointestinal imaging techniques: radionuclide testing, colonic transit studies, and virtual colonoscopy.
Radionuclide Testing
Radionuclide testing is a sophisticated medical technique for assessing gastrointestinal motility. It focuses on gastric emptying and colonic transit time. Radioactive markers track the movement of food through the digestive system, providing insights into gastrointestinal disorders.
In gastric emptying studies, a meal's liquid and...
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Computed Tomography01:10

Computed Tomography

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Tomography refers to imaging by sections. Computed tomography (CT) is a non-invasive imaging technique that uses computers to analyze several cross-sectional X-rays to reveal minute details about structures in the body.
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...
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相关实验视频

Updated: Jul 12, 2025

Near Infrared Optical Projection Tomography for Assessments of β-cell Mass Distribution in Diabetes Research
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Near Infrared Optical Projection Tomography for Assessments of β-cell Mass Distribution in Diabetes Research

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使用计算方法数字化TIM-1模型─第二部分:GastroPlus中的数字TIM-1模型

Bart Hens1, Inese Sarcevica1, Irena Tomaszewska1

  • 1Drug Product Design, Pfizer, Discovery Park, Ramsgate Road, Sandwich CT13 9ND, U.K.

Molecular pharmaceutics
|October 25, 2023
PubMed
概括

在GastroPlus中的一个新的数字TIM-1胃肠道模型准确地预测了药物的生物可用性. 这种经过验证的工具有助于药物开发,通过在各种条件下评估生物可访问的药物成分,改善体外-体内相关性.

关键词:
在 PBPK 建模中使用 PBPK 模型.在TNO肠道模型 (TIM-1) 中.在模拟模型中.在体外溶解溶解.口服生物制药是什么意思

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相关实验视频

Last Updated: Jul 12, 2025

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科学领域:

  • 药理动力学和药物新陈代谢
  • 计算机建模和模拟
  • 药物产品开发 药物产品开发

背景情况:

  • TIM-1模型模拟胃肠道条件,以预测体内药物释放和生物可用性.
  • 准确预测可生物利用的药物成分对于非临床药物开发至关重要.
  • 现有的模型需要对各种生理和配方条件进行验证.

研究的目的:

  • 在 GastroPlus 平台内开发和验证数字 TIM-1 模型.
  • 评估模型预测光度和生物可访问分量的能力.
  • 评估数字TIM-1模型在不同生理条件下预测药物行为的性能.

主要方法:

  • 在GastroPlus软件中集成的数字TIM-1模型的开发.
  • 验证实验使用两个标记化合物在被养和禁食状态下进行验证实验.
  • 使用 PF-07059013 在不同剂量和化条件下进行的案例研究.

主要成果:

  • 数字TIM-1模型准确地反映了标记化合物的光度和生物可访问分数.
  • 模型预测与PF-07059013的实验数据保持一致,特别是显示了对溶解度有限溶解的化效应.
  • 该模型证明了质量转移的适当整合和预测的剂量依赖效应.

结论:

  • 在GastroPlus中验证的数字TIM-1模型是预测体外药物释放和生物可用性的可靠工具.
  • 这种数字模型有助于评估关键生物可用性属性,并有助于配方开发.
  • 未来的应用包括建立体外-体内相关性 (IVIVC) 以提高药物开发.