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Updated: Jan 12, 2026

Combining Human Organoids and Organ-on-a-Chip Technology to Model Intestinal Region-Specific Functionality
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建立人类十二指肠芯片作为有效的人类透性的替代品:在体外和在体内评估.

Kellyn M Patros Zagaja1, Anna K Kopec1, Julie Harney1

  • 1Pfizer Research and Development, Pfizer Inc., Groton, Connecticut, 06340, USA.

The AAPS journal
|October 31, 2025
PubMed
概括

芯片上的器官提供了一个针对人类的药物透性评估平台,改善了口服生物利用率的预测,并减少了对动物模型的依赖.

关键词:
在 PBPK 建模中使用 PBPK 模型.生物制药 生物制药 生物制药口服吸收 口服吸收器官在芯片上的器官有机生物有机物透性 透性的

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Methods for Studying Drug Absorption: In vitro01:16

Methods for Studying Drug Absorption: In vitro

In vitro experiments are crucial for understanding the transport and absorption of drugs through biological materials. These studies employ varied methods such as the diffusion cell method, the everted sac technique, and the everted ring technique.
The diffusion cell method uses a two-compartment cell, including a donor compartment with the drug solution, which simulates the environment where the drug is applied, and a receptor compartment with a buffer solution, which simulates the environment...
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