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相关概念视频

Open Angle Glaucoma: Treatment01:27

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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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Angle Closure Glaucoma: Treatment01:28

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Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
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通过降低眼内压力减少HIF-1α减轻了视网膜新血管化.

Ziqi Yang1, Biyan Ni1, Tian Zhou1

  • 1State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou 510060, China.

Biomolecules
|October 28, 2023
PubMed
概括

用于眼睛注射的较大的针头通过降低眼内压力,意外地减少了视网膜新血管化. 这一发现表明,降低眼内压力可能是治疗盲目眼睛疾病的新方法.

关键词:
缺氧诱导因子-1α (HIF-1α)眼内压力 (IOP) 是指眼内压力.内注射 内注射 内注射氧气引起的视网膜病变 (OIR)视网膜新血管化疗法

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科学领域:

  • 眼科医生 眼科 眼科
  • 血管新生研究研究
  • 血管生物学 血管生物学

背景情况:

  • 由缺氧驱动的视网膜新血管化是导致失明的主要原因.
  • 氧气诱导视网膜病变 (OIR) 模型对于研究抗血管性疗法至关重要.
  • 静脉内注射是OIR模型中提供治疗的标准.

研究的目的:

  • 为了研究不同内穿孔大小对视网膜新血管化的影响.
  • 探索观察到的抗血管原效应的潜在机制.
  • 评估眼内压力 (IOP) 降低作为治疗策略的潜力.

主要方法:

  • 在OIR小鼠中,进行了不同尺寸的针 (0.5毫米,0.3毫米,0.21毫米) 的内穿孔.
  • 评估了视网膜新血管化,血管泄漏和视网膜血管结构.
  • 测量眼内压力 (IOP),氧气局部压力 (pO2) 和低氧诱导因子1-α (Hif1a) 表达.
  • 评估了降压药物 (Travatan,Azarga) 的疗效.

主要成果:

  • 与较小的针相比,0.5毫米针刺穿显著抑制了病态血管生成和血管泄漏.
  • 0.5毫米的刺穿导致IOP显著降低,改善氧化和减少Hif1a表达.
  • 降低内血压的药物通过减轻缺氧,显示出强大的抗血管生成作用.
  • 降低IOP与抑制的HIF-1α介导的视网膜新血管化直接相关.

结论:

  • 静脉内注射针的大小显著影响视网膜新血管化.
  • 一个更大的穿孔 (0.5毫米) 诱导急性IOP降低,抑制缺氧和HIF-1α.
  • 降低眼内压力是视网膜神经血管疾病的一种有前途的治疗方法.