Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Psychoneuroimmunology: Cardiovascular Disease01:27

Psychoneuroimmunology: Cardiovascular Disease

33
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
33
Inflammatory Response I: Vascular and Cellular01:30

Inflammatory Response I: Vascular and Cellular

11.2K
The inflammatory response is the body's defense against infection, injury, or irritation from bacteria, trauma, toxins, or heat. Inflammation helps locate and destroy pathogens and remove damaged tissue elements to heal the body. During this initial phase, fluid, blood products, and nutrients migrate to the injured area, resulting in redness, heat, swelling, ache, and loss of function. Moreover, signs of systemic inflammation include fever, increased WBC count, malaise, anorexia, nausea,...
11.2K
Intracellular Signaling Affects Focal Adhesions01:17

Intracellular Signaling Affects Focal Adhesions

2.7K
Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
Some...
2.7K
Introduction to Stress and Lifestyle01:27

Introduction to Stress and Lifestyle

124
Stress is a multifaceted response to events perceived as challenging or threatening, highlighting physical, emotional, cognitive, and behavioral reactions. Physically, stress can lead to fatigue, sleep disruptions, and various health issues such as frequent colds, chest pains, and nausea. Emotionally, it can manifest as anxiety, depression, irritability, and anger triggered by both minor and major life events. Cognitively, it may result in difficulty in concentration, memory, and...
124
Chromatin Modification in iPS Cells01:32

Chromatin Modification in iPS Cells

1.7K
Chromatin modification alters gene expression; therefore, scientists can add histone-modifying enzymes, histone variants, and chromatin remodeling complexes to somatic cells to aid reprogramming into pluripotent stem (iPS) cells.
Compact chromatin makes reprogramming difficult. Enzymes, such as histone demethylases and acetyltransferases, are often added during reprogramming to loosen the chromatin, making the DNA more accessible to transcription factors. Molecules that inhibit histone...
1.7K
Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

2.6K
Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
2.6K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Long noncoding RNA MALAT1 can regulate proliferation and apoptosis of LPS-treated HK-2 cells via targeting miR-23a-3p through regulating ERK signaling.

Archives of medical science : AMS·2025
Same author

Identification of a panel of volatile organic compounds in urine for early detection of for bladder cancer.

Scientific reports·2025
Same author

A <i>Clostridium perfringens</i> Related Foodborne Diarrhea Outbreak in an Elderly Care Center - Beijing Municipality, China, May 2024.

China CDC weekly·2025
Same author

Mixed lineage kinase (MLK) controls tumor development and angiogenesis.

Angiogenesis·2025
Same author

Regulatory T cells: a promising new therapeutic target in ventricular remodeling after myocardial infarction.

Frontiers in immunology·2025
Same author

Prognostic significance of different lymph node staging systems in patients with resectable, node-positive, stage III, non-small cell lung cancer: Identifying the optimal classification for enhanced prognostic stratification.

Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique·2025

相关实验视频

Updated: Jul 12, 2025

On-Chip Endothelial Inflammatory Phenotyping
12:43

On-Chip Endothelial Inflammatory Phenotyping

Published on: July 21, 2012

11.0K

炎症性压力介导的染色质变化是内皮细胞功能障碍的基础.

Haibo Liu1, Amada D Caliz2, Heather Learnard3

  • 1Molecular, Cell and Cancer Biology Department, University of Massachusetts Chan Medical School, Worcester, MA, USA.

bioRxiv : the preprint server for biology
|October 31, 2023
PubMed
概括

炎症应激会改变内皮细胞的染色质,影响心血管健康. 这项研究揭示了与核细胞相关的中间体的变化,以及在压力期间增加的中心体基因转录.

关键词:
这就是TNF-alpha.它们是中间体 (centromeres).在这种情况下,染色染色素细胞因子 细胞因子发烧 发烧 发烧 发烧热应激是一种热应激.异性染色是一种异性染色.这是一种炎症炎症炎症炎症.压力就是压力,压力就是压力.血管内皮细胞是血管内皮细胞.

更多相关视频

En Face Preparation of Mouse Blood Vessels
10:01

En Face Preparation of Mouse Blood Vessels

Published on: May 19, 2017

21.2K
The Assembly and Application of 'Shear Rings': A Novel Endothelial Model for Orbital, Unidirectional and Periodic Fluid Flow and Shear Stress
09:20

The Assembly and Application of 'Shear Rings': A Novel Endothelial Model for Orbital, Unidirectional and Periodic Fluid Flow and Shear Stress

Published on: October 31, 2016

8.1K

相关实验视频

Last Updated: Jul 12, 2025

On-Chip Endothelial Inflammatory Phenotyping
12:43

On-Chip Endothelial Inflammatory Phenotyping

Published on: July 21, 2012

11.0K
En Face Preparation of Mouse Blood Vessels
10:01

En Face Preparation of Mouse Blood Vessels

Published on: May 19, 2017

21.2K
The Assembly and Application of 'Shear Rings': A Novel Endothelial Model for Orbital, Unidirectional and Periodic Fluid Flow and Shear Stress
09:20

The Assembly and Application of 'Shear Rings': A Novel Endothelial Model for Orbital, Unidirectional and Periodic Fluid Flow and Shear Stress

Published on: October 31, 2016

8.1K

科学领域:

  • 心血管生物学 心血管生物学
  • 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
  • 细胞应激反应的应激反应

背景情况:

  • 炎症性压力与内皮功能障碍和慢性心血管疾病 (如动脉样硬化) 有关.
  • 虽然内皮细胞对炎症的转录反应已知,但对染色质结构的影响仍未得到充分研究.
  • 瘤坏死因子-α (TNF-α) 是一种关键的促炎性细胞因子,影响内皮细胞.

研究的目的:

  • 在炎症性压力 (TNF-alpha和热量) 下研究人类内皮细胞中的染色质变化.
  • 探索染色质可访问性,基因转录和内皮功能障碍驱动因素之间的关系.
  • 检查在炎症应激过程中核组织的动态变化,特别是中心分子-核相互作用.

主要方法:

  • 综合分析ATAC-seq (使用测序测定转移酶可访问染色质的测试) 和RNA-seq (核糖核酸测序) 数据.
  • 用显微镜观察核组织动态.
  • 研究p38激酶在压力诱导的染色质变化中的作用.

主要成果:

  • 多omics分析揭示了与压力相关的基因转录,内皮功能障碍驱动因素和差异性染色质可访问性之间的相关性.
  • 显微镜显示了核组织的动态变化,特别是在中间体异色域中.
  • 炎症性压力导致以p38依赖的方式降低了中间体-核关联,并增加了来自周周中心体区域的转录.

结论:

  • 在炎症性压力期间,血管内皮细胞发生染色质变化.
  • 中心细胞局部化和周心细胞转录的变化表明,一种新的机制将炎症,染色体动力学和内皮功能障碍联系起来.
  • 这些发现为心血管疾病的表观遗传调节提供了新的见解.