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相关概念视频

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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Regulation of the Unfolded Protein Response01:31

Regulation of the Unfolded Protein Response

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Inositol-requiring kinase one or IRE1 is the most conserved eukaryotic unfolded protein response (UPR) receptor. It is a type I transmembrane protein kinase receptor with a distinctive site-specific RNase activity. As the binding mechanics of the misfolded proteins with the N-terminal domain of IRE-1 are unclear, three binding models — direct, indirect, and allosteric -- are proposed for receptor activation. Nevertheless, it is known that once a misfolded protein associates with IRE1, it...
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Exercise and Cardiovascular Response01:20

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Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
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Nuclear Export of mRNA02:31

Nuclear Export of mRNA

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Before mRNAs are exported to the cytoplasm, it is crucial to check each mRNA for structural and functional integrity. Eukaryotic cells use several different mechanisms, collectively known as mRNA surveillance, to look for irregularities in mRNAs. Irregular or aberrant mRNA are rapidly degraded by various enzymes. If a defective mRNA escapes the surveillance, it would be translated into a protein which would either be non-functional or not function properly. One of the primary irregularities in...
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相关实验视频

Updated: Jul 11, 2025

Assessment of Murine Exercise Endurance Without the Use of a Shock Grid: An Alternative to Forced Exercise
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运动免疫学中的非编码RNA:系统性审查

Mona Kotewitsch1, Melina Heimer1, Boris Schmitz1

  • 1Department of Rehabilitation Sciences, Faculty of Health, University of Witten/Herdecke, Witten 58455, Germany; DRV Clinic Königsfeld, Center for Medical Rehabilitation, Ennepetal 58256, Germany.

Journal of sport and health science
|November 4, 2023
PubMed
概括

定期运动通过非编码RNAs (ncRNAs) 调节免疫功能. 本综述确定了关键的microRNAs (miRNAs) 及其标,揭示了它们在运动诱导的免疫反应中的重要作用,特别是在耐力运动后.

关键词:
免疫系统的免疫系统.炎症 炎症是一种炎症.这是一个微型RNA.身体炼是一种体力炼.这是一个ncRNARNA.

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科学领域:

  • 免疫学和运动科学
  • 分子生物学和遗传学分子生物学和遗传学

背景情况:

  • 运动显著影响免疫功能,影响监测,炎症和整体健康.
  • 非编码RNAs (ncRNAs) 参与免疫调节,但缺乏运动调节的ncRNAs及其免疫点的全面列表.
  • 现有研究表明,研究设计和炼方案的异质性,需要一个系统的方法.

研究的目的:

  • 通过体育炼系统地识别和分类参与免疫调节的ncRNA.
  • 创建一个功能性,运动依赖的ncRNAs与已知的免疫系统目标的缩小列表.
  • 分析特定的microRNAs (miRNAs) 在调解运动诱导的免疫效应中的作用.

主要方法:

  • 一项系统性审查和定性分析,结合文献搜索 (PubMed, Web of Science, SPORTDiscus) 的"ncRNA和运动免疫学"和数据库搜索 (miRTarBase, DIANA-Tarbase v8) 的针对免疫基因的miRNA (Reactome数据库).
  • 纳入标准侧重于健康人群的基于运动的干预措施,miRNA目标通过体外实验数据验证.
  • 使用排序表合成结果,根据运动方式,干预类型 (急性/慢性) 和跨研究报告的变化一致性 (验证,可信,暗示性) 来分类ncRNA.

主要成果:

  • 对95项研究的分析确定了164种miRNA和6种其他ncRNA (lncRNA,循环RNA) 参与运动免疫学.
  • 对于抵抗运动,miR-206的上调得到了验证,miR-133a的下调是合理的.
  • 15个miRNA被验证用于耐力运动,12个持续上调,3个下调,主要是在急性运动后. 关键的miRNAs包括miR-15,miR-29c,miR-30a,miR-142/3,miR-181a和miR-338. 这三种基因组分别具有重要的作用.

结论:

  • 微RNAs (miRNAs) 在运动诱导的免疫系统调节中起着至关重要的作用,影响免疫细胞的分布,功能,贩运和细胞因子的产生.
  • 特定的miRNAs,特别是miR-15,miR-29c,miR-30a,miR-142/3,miR-181a和miR-338,是运动免疫调节效应的关键媒介,特别是在急性耐力运动后.
  • 这种系统的方法提供了一份经过验证的运动反应性ncRNAs清单,增强了我们对运动和免疫之间的分子机制的理解.